摘要
目的探讨肝癌衍生生长因子(HDGF)的表达与口腔癌患者预后的相关性。方法回顾性分析2019年3月—2023年1月东南大学医学院附属南京同仁医院收治的96例口腔癌患者的临床资料,收集口腔癌患者活检癌组织标本及距肿物边缘>3 cm的癌旁组织。比较癌组织、癌旁组织中HDGF表达情况,并分析HDGF表达情况对患者预后的影响。患者术后随访36个月,比较随访期间HDGF阴性和阳性表达口腔癌患者的生存率。结果口腔癌患者癌组织中HDGF的阳性表达率[75.00%(72/96)]高于癌旁组织[11.46%(11/96)](P<0.05);不同性别、年龄、BMI及吸烟、饮酒情况的口腔癌患者癌组织中HDGF阳性表达率比较,差异无统计学意义(均P>0.05);肿瘤长径≥3 cm、临床分期Ⅲ~Ⅳ期、有淋巴结转移、低分化、有脉管侵犯的口腔癌患者癌组织中HDGF阳性表达率分别高于肿瘤长径<3 cm、临床分期Ⅰ~Ⅱ期、无淋巴结转移、中/高分化、无脉管侵犯患者(均P<0.05);Cox回归分析显示肿瘤长径、合并牙周炎或牙髓炎、吸烟、临床分期、淋巴结转移、组织学类型及HDGF阳性表达是口腔癌患者总生存率的独立影响因素(均P<0.05);截至随访结束,HDGF阳性表达患者总存活率为70.77%(46/65),HDGF阴性表达患者总存活率为95.45%(21/22),HDGF阴性表达患者的存活率高于阳性表达患者(P<0.05)。结论口腔癌患者癌组织中HDGF呈现异常高表达,且与临床病理特征及预后均具有密切关系。
Objective To investigate the correlation between the expression of hepatoma-derived growth factor(HDGF)and the prognosis of patients with oral cancer.MethodsClinical data of 96 patients with oral cancer admitted to Nanjing Tongren Hospital,School of Medicine,Southeast University from March 2019 to January 2023 were retrospectively analyzed,and biopsy cancer tissue specimens and adjacent tissues>3 cm from the tumor margin of oral cancer patients were collected.The expression of HDGF in cancer tissues and adjacent tissues was compared,and the influence of HDGF expression on prognosis of patients was analyzed.The patients were followed up for 36 months to compare the survival rate of patients with HDGF-negative and HDGF-positive oral cancer during follow-up.ResultsThe positive expression rate of HDGF in oral cancer tissues[75.00%(72/96)]was higher than that in adjacent tissues[11.46%(11/96)](P<0.05).There was no significant difference in the positive expression rate of HDGF in oral cancer patients with different sex,age,body mass index(BMI),smoking and drinking conditions(P>0.05).The positive expression rate of HDGF in oral cancer tissues of patients with tumor length≥3 cm,clinical stageⅢ-Ⅳ,lymph node metastasis,low differentiation,and vascular invasion was higher than that of patients with tumor length<3 cm,clinical stageⅠ-Ⅱ,no lymph node metastasis,medium/high differentiation,and no vascular invasion(all P<0.05).Cox regression analysis showed that tumor length,periodontitis or pulpitis,smoking,clinical stage,lymph node metastasis,histological type and positive expression of HDGF were independent influencing factors for overall survival of patients with oral cancer(all P<0.05).By the end of follow-up,the overall survival rate of patients with positive expression of HDGF was 70.77%(46/65),and that of patients with negative expression of HDGF was 95.45%(21/22).The survival rate of patients with negative expression of HDGF was higher than that of patients with positive expression(P<0.05).ConclusionsThe expression of HDGF in oral cancer tissues is abnormally high,which is closely related to clinicopathological features and prognosis.
作者
刘乙圻
张慧
王甜坤
Liu Yiqi;Zhang Hui;Wang Tiankun(Department of Stomatology,Nanjing Tongren Hospital,School of Medicine,Southeast University,Nanjing 210000,China;Department of Stomatology,Qinhuai Hospital of Traditional Chinese Medicine,Nanjing 210000,China)
出处
《中国医师杂志》
2025年第1期42-46,共5页
Journal of Chinese Physician
基金
江苏省自然科学基金(BK20200149)。
关键词
肝癌衍生生长因子
口腔肿瘤
Hepatoma-derived growth factor
Mouth neoplasms
