摘要
膜联蛋白A3(ANXA3)属于膜联蛋白家族成员,具有36 kDa和33 kDa两个亚型,其基因位于人第4号染色体上。ANXA3在人体骨髓、肺、胎盘、前列腺和甲状腺等组织中表达,与胞吐、血管生成、脂肪细胞成熟和白细胞迁移等生物学过程密切相关。研究发现,ANXA3在癌症、心血管疾病和炎症等疾病中异常表达,可以调控JNK、NF-κB、PI3K/Akt等多条信号通路,可能成为相关疾病的治疗靶点。该文主要就ANXA3的结构、功能、与疾病的联系以及相关机制进行综述,以期为ANXA3的相关研究提供借鉴。
Annexin A3(ANXA3)is a member of the membrane associated protein family.It has two subtypes of 36 kDa and 33 kDa.Its gene is located on the fourth chromosome of human.ANXA3,widely expressed in human bone marrow,lung,placenta,prostate and thyroid,is closely related to several biological processes such as exoplasmosis,vascular production,fat cell maturity,and white blood cell migration.Studies have found that ANXA3 is abnormally expressed in various diseases including cancer,cardiovascular disease and inflammation.It can regulate multiple signaling pathways such as JNK,NF-κB,PI3K/AKT,and may become a potential drug target for treatment of related diseases.The structure,functions,the link with diseases and related mechanisms of ANXA3 were summarized in this paper,which could provide reference for ANXA3 related research.
作者
冯婷婷
张景翔
王彦
许维恒
张俊平
FENG Tingting;ZHANG Jingxiang;WANG Yan;XU Weiheng;ZHANG Junping(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《药学实践与服务》
2025年第2期47-50,74,共5页
Journal of Pharmaceutical Practice and Service
