摘要
酒精性肝病(alcoholic liver disease,ALD)作为全球慢性肝病的主要病因,对人类健康构成了严重威胁。尽管目前已有多种药物用于治疗ALD,但疗效并不确切,因此迫切需要寻找新的治疗途径。近年来,中药多糖因其多功能性、高效性和低不良反应而备受关注,并在防治ALD方面展现巨大潜力。越来越多的研究表明,中药多糖可以通过抑制氧化应激、调节脂质代谢、调节肠道菌群及调控程序性细胞死亡等多种作用机制改善ALD。该文综述了近年来中药多糖在抗ALD药理作用及其调控机制方面的研究进展,旨在为中药多糖在ALD的预防和治疗中提供科学依据和理论支撑。
Alcoholic liver disease(ALD),a major cause of chronic liver disease worldwide,poses a serious threat to human health.Despite the availability of various drugs for treating ALD,their efficacy is often uncertain,necessitating the search for new therapeutic approaches.Traditional Chinese medicine polysaccharides have garnered increasing attention in recent years due to their versatility,high efficiency,and low side effects,and they have demonstrated significant potential in preventing and treating ALD.Emerging studies have suggested that these polysaccharides exert their therapeutic effects through multiple mechanisms,including the inhibition of oxidative stress and the regulation of lipid metabolism,gut microbiota,and programmed cell death.This review summarizes the recent research progress in the pharmacological effects and regulatory mechanisms of traditional Chinese medicine polysaccharides in treating ALD,aiming to provide a scientific basis and theoretical support for their application in the prevention and treatment of ALD.
作者
陈昱帆
姜何
马青
骆启晗
黄朔
邱将
陈傅喆
单子怡
邱萍
CHEN Yu-fan;JIANG He;MA Qing;LUO Qi-han;HUANG Shuo;QIU Jiang;CHEN Fu-zhe;SHAN Zi-yi;QIU Ping(the Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China;School of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;the First School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China;School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《中国中药杂志》
北大核心
2025年第2期356-362,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金青年科学基金项目(82003830)
中国博士后科学基金第72批面上项目(2022M722852)
浙江中医药大学科研项目(2021JKZKTS016B)。
关键词
中药多糖
酒精性肝病
氧化应激
脂质代谢
程序性细胞死亡
肠-肝轴
traditional Chinese medicine polysaccharides
alcoholic liver disease
oxidative stress
lipid metabolism
programmed cell death
gut-liver axis
