摘要
目的探究分析盐酸氨溴索联合左氧氟沙星治疗对慢性支气管炎临床症状缓解时间的影响。方法选取2022年4月—2023年4月本科接诊的72例慢性支气管炎患者作为研究对象,并依据随机数列法将其均等地分为对照组与观察组。对照组患者仅接受盐酸氨溴索治疗,而观察组患者则接受盐酸氨溴索联合左氧氟沙星的治疗。比较两组患者在治疗有效率、血气指标、炎症因子指标、肺功能指标、临床症状缓解时间以及不良反应和肝肾功能异常情况方面的差异。结果相较于对照组,观察组治疗有效率更高(P<0.05);治疗后,观察组的血氧饱和度、动脉分压水平较高,二氧化碳分压、C反应蛋白以及降钙素原表达低(P<0.05);观察组的第一秒用力呼气容积与用力肺活量比值、最大呼气中段流量高于对照组,但最大呼气峰流速低于对照组(P<0.05);观察组的临床症状缓解时间各项数据均短于对照组(P<0.05)。两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论针对慢性支气管炎患者,采取盐酸氨溴索联合左氧氟沙星进行治疗能够发挥出更理想的治疗效果,且可有效抑制炎症的发展,安全性高。
Objective To explore and analyze application effect of ambroxol hydrochloride combined with levofloxacin in treatment of chronic bronchitis.Methods The paper chose 72 patients with chronic bronchitis in our department from April 2022 to April 2023 as research subjects,and divided them into the control and the observation groups based on a random sequence.Among them,the control group was treated with ambroxol hydrochloride only,while the observation group with ambroxol hydrochloride combined with levofloxacin.Curaitve effect,blood gas indicators,inflammatory factor indicators,lung function indicators,clinical symptom relief time,adverse reactions and liver and kidney dysfunction were compared between two groups.Results The observation group had higher effective rate of treatment than the control group,(P<0.05).After treatment,the blood oxygen saturation and arterial partial pressure of observation group were higher,and the expression of carbon dioxide partial pressure,C-reactive protein and procalcitonin were lower(P<0.05).The ratio of forced expiratory volume to forced vital capacity in the first second and the maximum mid-expiratory flow rate in the observation group were higher than those in the control group,but the maximum peak expiratory flow rate was lower than those in the control group(P<0.05).Clinical symptom relief time of the observation group was shorter than the control group(P<0.05).There was no statistically significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Combination of ambroxol hydrochloride and levofloxacin can achieve ideal curative effect,inhibit the development of inflammation of patients with chronic bronchitis effectively,which has high safety.
作者
高艾
GAO Ai(Wuwei City Liangzhou District Daliu Town Health Center,Wuwei,Gansu 733000)
出处
《智慧健康》
2024年第34期57-60,共4页
Smart Healthcare
