摘要
在哺乳动物的生长发育和损伤修复过程中,细胞器在受到来自机体内部或外界干扰时,通过一系列复杂的调控机制实现自我调节,以维持细胞稳态,这一过程被称为细胞器应激反应。高尔基体是细胞内一个关键的细胞器,不仅参与细胞内蛋白加工修饰、脂类代谢及囊泡转运等生理活动,还在离子稳态、应激反应中发挥着重要作用。骨代谢是一个维持骨骼健康的重要且复杂的过程,涉及成骨细胞、破骨细胞等多种细胞的协同作用。在这一过程中,高尔基体的应激反应有助于维持骨骼细胞的内稳态和生理功能。本文综述了高尔基体应激反应的研究进展,包括结构、功能、触发因素、信号转导途径,以及对骨组织细胞功能的影响,旨在为骨疾病的治疗提供新的思路。
During the growth,development,and injury repair processes of mammals,organelles undergo self-regulation through a series of complex regulatory mechanisms when subjected to interference from inside or outside,in order to maintain cellular homeostasis.This process is known as organelle stress response.The Golgi apparatus is a key organelle within the cell,not only participating in physiological activities such as the processing and modification of intracellular proteins,lipid metabolism,and vesicular transport,but also playing an important role in ion homeostasis and stress responses.Bone metabolism is an important and complex process for maintaining skeletal health,involving the coordinated action of various cells such as osteoblasts and osteoclasts.In this process,the stress response of the Golgi apparatus helps to maintain the intracellular homeostasis and physiological functions of bone cells.This article reviews the research progress on Golgi apparatus stress response,including its structure,function,triggering factors,signal transduction pathways,and its impact on the function of bone tissue cells,aiming to provide new insights for the treatment of bone diseases.
作者
牛萍萍
孙瑶
NIU Pingping;SUN Yao(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Shanghai Tongji Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)
出处
《口腔颌面外科杂志》
2025年第1期59-62,共4页
Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金优秀青年基金(81822012)。
关键词
高尔基体
细胞器
应激反应
糖基化
骨代谢
Golgi apparatus
organelle
stress response
glycosylation
bone metabolism
