摘要
目的:探讨自制理气活血化痰剂联合替罗非班、常规疗法治疗超溶栓时间窗急性脑梗死的临床效果。方法:选取2021年12月—2022年11月于泰安市中医医院就诊的超溶栓时间窗急性脑梗死患者76例进行研究,随机分为对照组(36例)、观察组(40例)。对照组接受替罗非班、常规疗法治疗,观察组在对照组基础上给予自制理气活血化痰剂治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.002)。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)、改良Barthel指数(ADL)评分比较,差异无统计学意义(P>0.05);治疗2周、3个月、6个月后,两组NIHSS评分下降,ADL评分升高,且观察组改善幅度大于对照组(P<0.05)。两组用药不良反应总发生率比较,差异无统计学意义(P<0.05)。结论:自制理气活血化痰剂联合替罗非班、常规疗法治疗超溶栓时间窗急性脑梗死的临床效果良好,可减轻神经损伤,提高患者日常生活能力,且不会增加不良反应。
Objective:To explore the clinical effect of self-made mixture of regulating qi,activating blood and resolving phlegm combined with tirofiban and conventional therapy in treatment of acute cerebral infarction beyond time window of thrombolysis.Methods:A total of 76 patients with acute cerebral infarction beyond time window of thrombolysis who were treated in Taian Tradi⁃tional Chinese Medicine Hospital from December 2021 to November 2022 were selected for study.They were randomly divided into control group(36 cases)and observation group(40 cases).The control group was treated with tirofiban and conventional therapy,and the observation group was treated with self-made mixture of regulating qi,activating blood and resolving phlegm on the basis of the control group.The treatment effects were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.002).Before treat⁃ment,there was no statistically significant difference in the scores of the National Institutes of Health Stroke Scale(NIHSS)and modified Barthel index(ADL)between the two groups(P>0.05).At 2 weeks,3 months and 6 months after treatment,the NIHSS score decreased and the ADL score increased in two groups,and the improvement in the observation group was greater than that in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P<0.05).Conclusion:The self-made mixture of regulating qi,activating blood and resolving phlegm combined with ti⁃rofiban and conventional therapy has good clinical effect in treatment of acute cerebral infarction beyond time window of throm⁃bolysis,and can alleviate nerve injury,improve patients'daily living ability,and will not increase adverse reactions.
作者
王秀春
肖贺
张丽丽
Wang Xiuchun;Xiao He;Zhang Lili(Taian Traditional Chinese Medicine Hospital,Taian 271000,Shandong Province,China;Shandong Province,China Beijing North Institute of Biotechnology Co.,Ltd,Beijing 100076,China)
出处
《中国社区医师》
2025年第4期66-68,共3页
Chinese Community Doctors
关键词
替罗非班
急性脑梗死
超溶栓时间窗
理气
活血化痰
Tirofiban
Acute cerebral infarction
Beyond time window of thrombolysis
Regulate qi
Activate blood and resolve phlegm
