摘要
人类免疫缺陷病毒1型(human immunodeficiency virus-1,HIV-1)对靶细胞的感染受到宿主细胞蛋白的限制,其中三基序蛋白(tripartite-motif protein,TRIM)家族是具有抗病毒作用和调节固有免疫反应的限制因子。TRIM22作为TRIM家族的一员,可被干扰素强烈上调,已被证明在抗HIV-1过程中发挥着重要作用,可通过调节自噬信号通路或转录因子特异蛋白1(specific protein 1,Sp1)来抑制病毒的复制及转录过程。本文主要阐述TRIM22结构、细胞定位及其抗HIV-1的作用机制,以期为HIV-1防治提供理论依据。
The infection of target cells by human immunodeficiency virus-1(HIV-1)is limited by hosts'cell proteins;among which,the tripartite motif protein(TRIM)family is an important limiting factor with antiviral effects and regulation of innate immune responses.TRIM22,as a member of the TRIM family,can be strongly upregulated by interferon,and has been shown to play an important role in the anti-HIV-1 process.It can inhibit virus replication and transcription regulating the autophagy signaling pathway or transcription factor specific protein 1(Sp1).This article mainly elaborates the structure,cellular localization,and mechanisms of TRIM22 in combating HIV-1,so as to provide theoretical basis for HIV-1 prevention and treatment.
作者
张子怡
孙大康
Zhang Ziyi;Sun Dakang(Laboratory Department,Binzhou Medical University Hospital,Binzhou 256600,China;Clinical Medical Research Center,Binzhou Medical University Hospital,Binzhou 256600,China)
出处
《国际医药卫生导报》
2025年第6期918-922,共5页
International Medicine and Health Guidance News
基金
研究生教育创新计划(2021478)。
关键词
人类免疫缺陷病毒1型
干扰素
三基序蛋白22
自噬
特异蛋白1
进展
Human immunodeficiency virus-1
Interferon
Tripartite motif protein 22
Autophagy
Specific protein 1
Progress
