摘要
目的探讨肝动脉插管化疗栓塞术(transcatheter arterial chemoembolization,TACE)与肝动脉灌注化疗术(hepatic artery infusion chemotherapy,HAIC)在原发性肝癌患者治疗中的应用效果对比。方法选取2023年1月至2024年1月前海人寿广州总医院收治的80例原发性肝癌患者,按随机数字表法分为对照组和观察组,各40例。对照组采取HAIC,观察组采用TACE。对比两组临床治疗效果、肿瘤标志物、肝功能指标及安全性。结果观察组总有效率为95.00%(38/40),高于对照组[80.00%(32/40)],差异有显著性(P<0.05)。治疗前,两组患者的肿瘤标志物及肝功能指标水平无显著差异(P>0.05);治疗后,观察组患者的血清癌胚抗原为(8.17±1.23)μg/L、糖类抗原125为(23.45±3.52)U/ml、谷草转氨酶为(51.66±5.24)U/L、谷丙转氨酶为(69.36±7.22)U/L、总胆红素为(15.79±2.67)μmol/L,显著低于对照组[分别为(9.65±1.14)μg/L、(28.97±3.29)U/ml、(62.70±6.35)U/L、(78.95±9.13)U/L、(19.45±3.06)μmol/L],差异均有显著性(P<0.05)。两组患者的并发症发生率相比,差异无显著性(P>0.05)。结论HAIC相比,TACE治疗原发性肝癌可获得更好的疗效,能降低肿瘤标志物,改善肝功能,安全性高。
Objective To compare the application eff ects of transcatheter arterial chemoembolization(TACE)and hepatic artery infusion chemotherapy(HAIC)in the treatment of primary liver cancer patients.Method 80 patients with primary liver cancer admitted to Guangzhou General Hospital of China Life Insurance from January 2023 to January 2024 were selected and randomly divided into two groups,with 40 patients in each group,using a random number table method.The control group was treated with HAIC,while the observation group was treated with TACE.Compare the clinical treatment effi cacy,tumor markers,liver function indicators,and safety between two groups.Result The total eff ective rate of the observation group was 95.00%(38/40),which was higher than that of the control group[80.00%(32/40)],and the diff erence was signifi cant(P<0.05).Before treatment,there was no signifi cant diff erence in the levels of tumor markers and liver function indicators between the two groups of patients(P>0.05);After treatment,the serum carcinoembryonic antigen of the observation group patients was(8.17±1.23)μg/L,carbohydrate antigen 125 was(23.45±3.52)U/ml,aspartate aminotransferase was(51.66±5.24)U/L,alanine aminotransferase was(69.36±7.22)U/L,and total bilirubin was(15.79±2.67)μmol/L,which were significantly lower than those of the control group[(9.65±1.14)μg/L,(28.97±3.29)U/ml,(62.70±6.35)U/L,(78.95±9.13)U/L,(19.45±3.06)μmol/L,respectively],and the diff erences were signifi cant(P<0.05).There was no signifi cant diff erence in the incidence of complications between the two groups of patients(P>0.05).Con-clusion Compared with HAIC,TACE treatment for primary liver cancer can achieve better effi cacy,reduce tumor markers,improve liver function,and has high safety.
作者
蒋政
温凯淋
查煌旗
郭正军
伍文静
Jiang Zheng;Wen Kailin;Zha Huangqi;Guo Zhengjun;Wu Wenjing(Intervention Department of Qianhai Life Insurance Guangzhou General Hospital,Guangdong Guangzhou 510000,China;Radiotherapy Department of Qianhai Life Insurance Guangzhou General Hospital,Guangdong Guangzhou 510000,China)
出处
《临床普外科电子杂志》
2025年第1期21-24,88,共5页
Journal of General Surgery for Clinicians(Electronic Version)
关键词
原发性肝癌
肝动脉插管化疗栓塞术
肝动脉灌注化疗术
效果
Primary liver cancer
Transcatheter arterial chemoembolization
Hepatic artery infusion chemotherapy
Effect
