摘要
目的探讨来曲唑与尿促性素治疗多囊卵巢综合征(PCOS)不孕患者的临床效果。方法选择2021年9月至2022年1月江西省妇幼保健院收治的60例PCOS不孕患者,行常规来曲唑方案(5 mg/d,连续5 d)促排卵失败。以随机数字表法分为观察组(n=30)、对照组(n=30)。观察组继续给予来曲唑,对照组给予尿促性素。比较两组性激素指标[睾酮(T)、黄体生成素(LH)、催乳素(PRL)、雌二醇(E2)、卵泡刺激素(FSH)]、促排卵情况、人绒毛膜促性腺激素(HCG)日子宫内膜的厚度和类型、排卵结局。结果促排前,两组性激素指标、周期失败率、未破裂卵泡黄素化综合征发生率、临床妊娠率、早期胚胎丢失率比较无统计学差异(P>0.05)。促排后,观察组T(21.16±2.67)ng/mL、E2(167.65±17.34)pg/mL、LH(6.84±1.15)IU/L、PRL(9.35±1.09)ng/mL均低于对照组[(28.78±3.41)ng/mL、(188.51±22.62)pg/mL、(7.81±1.36)IU/L、(11.82±1.25)ng/mL],FSH(7.45±1.66)U/L高于对照组的(6.08±0.79)IU/L(P<0.05)。观察组排卵率(96.67%)、子宫内膜厚度(9.84±0.87)mm、子宫内膜A型占比(66.67%)均高于对照组[73.33%、(8.38±0.71)mm、30.00%],多胎妊娠、卵巢过度刺激综合征(OHSS)发生率(2.67%、0.00%)均低于对照组(30.00%、20.00%),差异有统计学意义(P<0.05)。结论PCOS不孕症患者采用来曲唑治疗效果更佳,利于提高排卵率、妊娠率,改善性激素指标,减少多胎妊娠率,推广价值较高。
Objective To investigate the clinical efficacy of letrozole and follicle stimulating hormone in the treatment of infertility in patients with polycystic ovary syndrome(PCOS).Methods Sixty infertile patients with PCOS admitted to Jiangxi Maternity and Child Health Hospital from September 2021 to January 2022 were selected,and their ovarian stimulation failed after receiving the conventional letrozole regimen(5 mg/d for 5 consecutive days).They were divided into observation group(30 cases)and control group(30 cases)using a random number table method.Observation group continued to receive letrozole,while control group received gonadotropins.The sex hormone indicators[testosterone(T),luteinizing hormone(LH),prolactin(PRL),estradiol(E_2),follicle-stimulating hormone(FSH)],ovarian stimulation status,thickness and type of endometrium on the day of human chorionic gonadotropin(HCG)administration,and ovulation outcome were compared between the two groups.Results Before ovulation induction,there was no significant differencein hormone indicators,cycle failure rate,incidence of luteinizing syndrome in unruptured follicles,clinical pregnancy rate,and early embryo loss rate between the two groups(P>0.05).After ovulation induction,the T(21.16±2.67)ng/mL,E_2(167.65±17.34)pg/mL,LH(6.84±1.15)IU/L,and PRL(9.35±1.09)ng/mL in the observation group were all lower than those in the control group[(28.78±3.41)ng/mL,(188.51±22.62)pg/mL,(7.81±1.36)IU/L,and(11.82±1.25)ng/mL].FSH[(7.45±1.66)U/L]in the observation group was higher than that in the control group[(6.08±0.79)IU/L](P<0.05).The ovulation rate(96.67%),endometrial thickness[(9.84±0.87)mm],and proportion of type A endometrium(66.67%)in the observation group were higher than those in the control group[73.33%,(8.38±0.71)mm and 30.00%,respectively].The incidence of multiple pregnancies and ovarian hyperstimulation syndrome(OHSS)(2.67%,0.00%)were lower than those in the control group(30.00%,20.00%),and the difference was statistically significant(P<0.05).Conclusion The therapy of letrozole is more effective in treating PCOS infertility patients,which is beneficial for improving ovulation rate,pregnancy rate,improving sex hormone indicators,reducing multiple pregnancy rate,and has high promotion value.
作者
易迎春
YI Yingchun(Reproductive Health Department,Jiangxi Maternity and Child Health Hospital,Nanchang Jiangxi 330000,China)
出处
《天津药学》
2025年第2期202-205,共4页
Tianjin Pharmacy
基金
江西省卫生健康委科技计划(202211083)。
关键词
多囊卵巢综合征
不孕
来曲唑
性激素指标
Polycystic ovary syndrome
Infertility
Letrozole
Sex hormone indicators
