摘要
目的探究带状疱疹后神经痛患者予以西酞普联合兰普瑞巴林治疗对其疼痛、负性情绪的影响。方法选择103例2022年9月至2023年3月于我院治疗的带状疱疹神经痛患者为研究对象,随机分为观察组(n=52)及对照组(n=51),其中观察组接受西酞普联合兰普瑞巴林治疗,对照组仅接受普瑞巴林治疗。比较两组患者临床疗效、疼痛感受、焦虑、抑郁情况及细胞因子变化情况。结果观察组有效率高于对照组(94.23%vs 64.71%,P<0.05)。治疗后,两组视觉模拟评分、汉密顿焦虑量表评分、汉密顿抑郁量表评分以及细胞因子白介素-6、肿瘤坏死因子-α水平均较治疗前降低,且观察组均低于对照组(P<0.05)。结论普瑞巴林联合西酞普兰治疗带状疱疹后神经痛患者能提升临床疗效,减轻患者疼痛感受,改善其焦虑、抑郁情况,降低炎症因子水平。
Objective To investigate the effect of citalopram combined with pregabalin on pain degree and negative emotions in patients with postherpetic neuralgia.Methods A total of 103 patients with postherpetic neuralgia treated in our hospital from September 2022 to March 2023 were selected as the study objects.They were randomly divided into the observation group(n=52)and the control group(n=51).The observation group received pregabalin combined with citalopram,while the control group received pregabalin.The clinical efficacy,pain degree,anxiety,depression and cytokine changes were compared between the two groups.Results The clinical efficacy rate of the observation group was higher than that of the control group(94.23%vs 64.71%,P<0.05).After treatment,the visual analogue scale,Hamilton Anxiety Scale,Hamilton Depression Scale,the levels of interleukin-6 and tumor necrosis factor-αin the both groups were decreased than those before treatment,and the observation group was lower than the control group(P<0.05).Conclusion Pregabalin combined with citalopram can improve the clinical efficacy,effectively alleviate the pain,ameliorate the anxiety and depression,and attenuate the inflammation response in patients with postherpetic neuralgia.
作者
何宇
何伟
杜静
HE Yu;HE Wei;DU Jing(Department of Pain,Mianyang Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan Province,China)
出处
《世界临床药物》
2025年第1期60-65,共6页
World Clinical Drug
