摘要
目的 探讨乙肝肝硬化患者经自拟散结退黄汤治疗前后的肝功能指标变化。方法 研究对象:前瞻性选取河南科技大学第一附属医院收治的乙肝肝硬化患者(样本量:66),纳入时间:2021年1月到2023年10月,分为常规西药组(33例,替诺福韦酯)与联合中医组(33例,替诺福韦酯+自拟散结退黄汤)(分组依据:随机),均持续治疗24周,其中常规西药组失访3例,联合中医组失访1例,最终纳入62例:常规西药组(30例)、联合中医组(32例),比较两组治疗后临床疗效,治疗前及治疗后中医证候积分、肝功能,治疗期间不良反应发生情况。结果 治疗后相比常规西药组,联合中医组的临床总有效率处于更高水平;相比治疗前的各项中医证候积分与全血ALT、AST、TBil水平,治疗后两组上述指标均呈现降低趋势,相比治疗前的全血ALB水平,治疗后两组均呈现升高趋势,且联合中医组的变化更为明显(P<0.05)。结论 临床上在对乙肝肝硬化患者治疗方案的选取中,常规西医联合自拟散结退黄汤在多方面(改善中医证候、肝功能、提升用药安全性等)均更具优势。
Objective To investigate the changes of liver function indexes in patients with hepatitis B cirrhosis before and after treatment with self-made Sanjie Tuihuang Decoction.Methods Subjects:Patients with hepatitis B cirrhosis admitted to the First Affiliated Hospital of Henan University of Science and Technology(sample size:66)were prospectively selected,and the inclusion time was from January 2021 to October 2023.They were divided into conventional western medicine group(33 cases in tenofovir disoproxil fumarate)and combined traditional Chinese medicine group(33 cases in tenofovir disoproxil fumarate+self-made Sanjie Tuihuang Decoction)(grouping basis:random).Both groups were treated for 24 weeks.Among them,3 cases in conventional western medicine group were lost to follow-up,1 case in the combined traditional Chinese medicine group was lost to follow-up,and 62 cases were finally included:conventional western medicine group(30 cases)and combined traditional Chinese medicine group(32 cases).The clinical efficacy after treatment,TCM syndrome scores before and after treatment,liver function,and adverse reactions during treatment were compared between the two groups.Results After treatment,compared with the conventional western medicine group,the clinical total effective rate of the combined traditional Chinese medicine group was at a higher level;Compared with the scores of TCM syndromes before treatment and the levels of ALT,AST and TBil in whole blood,the above indexes of the both groups showed a downward trend after treatment.Compared with the whole blood ALB level before treatment,both groups showed an increasing trend after treatment,and the change in the combined traditional Chinese medicine group(P<0.05).Conclusion Clinically,in the selection of treatment schemes for patients with hepatitis B cirrhosis,conventional western medicine combined with self-made Sanjie Tuihuang Decoction has advantages in many aspects(improving TCM syndromes,liver function,improving medication safety,etc).
作者
邵丹丹
SHAO Dan-dan(Department of Infectious Diseases,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第3期94-96,共3页
Journal of Rare and Uncommon Diseases
关键词
乙肝肝硬化
替诺福韦酯
自拟散结退黄汤
肝功能
Hepatitis B Cirrhosis
Tenofovir Disoproxil
Self-made Sanjie Tuihuang Decoction
Liver Function
