摘要
抗逆转录病毒疗法(ART)是艾滋病患者治疗的有效方法,但是治疗是终身的并且艾滋病并没有治愈。即使在接受治疗后,病毒得到抑制且CD4+T细胞计数恢复良好的患者,与健康人群相比,他们依然面临更高的艾滋病及非艾滋病事件发生风险。因此,科学界认为有必要寻找新的适用于临床实践的生物标志物,以便识别由于疾病进一步发展或并发疾病风险增加而需要进行密切监测的患者。近年来,许多研究强调CD4/CD8比值可能是预测艾滋病及非艾滋病事件的一个很好的生物标志物,这一观点逐渐受到关注。通过整理近年来相关文献,文章就CD4/CD8比值对预测艾滋病患者预后的应用潜力进行综述,期望为优化艾滋病患者的监测、治疗方案和并发事件的预防提供理论支持。
Antiretroviral therapy(ART)is an effective way to treat people with AIDS,but treatment is lifelong and it cannot cure AIDS.Even if the virus is suppressed and CD4+T cell counts recover well after treatment,they are still at higher risk of developing AIDS and non-AIDS events compared to healthy people.Therefore,the academic and research community believes that it is necessary to search for new biomarkers applicable to clinical practice in order to identify patients who need to be closely monitored due to further disease progression or increased risk of co-morbidities.In recent years,many studies have emphasized that the CD4/CD8 ratio may be a good biomarker for predicting AIDS and non-AIDS events.By sorting out relevant literature in recent years,the article reviews the po‐tential application of CD4/CD8 ratio in predicting the prognosis of HIV-infected people,hoping to provide substantial support for opti‐mizing the monitoring,treatment and prevention of concurrent events in HIV-infected people.
作者
王艺晓(综述)
邱涛(综述)
朱宝立(综述)
张之(审校)
WANG Yixiao;QIU Tao;ZHU Baoli;ZHANG Zhi(School of Public Health,Nanjing Medical University,Nanjing 210000,Jiangsu,China;Jiangsu Provincial Cen-ter for Disease Prevention and Control,Nanjing 210009,Jiangsu,China)
出处
《医学研究与战创伤救治》
北大核心
2025年第1期97-101,共5页
Journal of Medical Research & Combat Trauma Care
基金
江苏省医学重点学科(ZDXK202249)。
