摘要
运动因子(Exerkines)作为由骨骼肌及其他组织分泌的生物活性物质,在调节神经系统功能、改善神经炎症、促进神经修复等方面具有重要作用。系统探讨运动因子的来源、转运机制及其在神经精神疾病中的作用,详细阐述运动因子的神经生物功能,并探讨其在神经精神疾病精准干预中的潜力。运动因子可分为骨骼肌源性因子、心源性因子、肝源性因子、脂肪源性因子和神经源性因子等,其神经生物学功能包括神经修复与再生、神经炎症调节、神经发育等。在运动的诱导下,这些因子通过血液循环或囊泡转运等方式传递信息,并在靶组织中发挥作用。在神经精神疾病的精准干预中,可通过运动因子进行个性化评估、精准诊断和治疗监测。通过整合生物组学、神经影像学及数据分析技术,可以更全面地了解运动因子的功能机制,并为疾病的精准干预提供科学依据。
Exerkines,which serves as bioactive substances secreted by skeletal muscles and other tissues,play a crucial role in regulating nervous system function,improving neuroinflammation and promoting neurorepair.This study systematically explores the sources,transport mechanisms and the roles of exerkines in neuropsychiatric disorders,elaborates their neurobiological functions and the potential in precise interventions for neuropsychiatric disease treatment.Exerkines can be categorized into myokines,cardiokines,hepatokines,adipokines and neurokines.Their neurobiological functions include neural repair and regeneration,regulation of neuroinflammation and neurodevelopment.The factors induced by exercises transmit messages through blood circulation or vesicular transport,and exert effects on target tissues.In the precise intervention of neuropsychiatric disorders,exerkines can be utilized for personalized assessment,precise diagnosis and treatment monitoring.By integrating omics,neuroimaging and data analysis technologies,a more comprehensive understanding of the functional mechanisms of exerkines can be obtained,providing scientific evidence for precise intervention in diseases.
作者
刘微娜
章森
何文柯
漆正堂
LIU Weina;ZHANG Sen;HE Wenke;QI Zhengtang(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;College of Physical Education and Health,East China Normal University,Shanghai 200241,China)
出处
《上海体育大学学报》
北大核心
2025年第3期35-51,74,共18页
Journal of Shanghai University of Sport
基金
国家自然科学基金项目(32271174)
国家社会科学基金重点项目(23AZD092)
教育部人文社会科学研究规划基金项目(23YJA890022)
中央高校基本科研业务费项目(2024QKT005、43800-20102-222000/006/014)。
关键词
运动因子
精准干预
神经精神疾病
神经生物学
exerkines
precision intervention
neuropsychiatric disorder
neurobiology
