摘要
目的分析2019年平顶山市疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)监测情况,评估平顶山市疫苗接种的安全性,为后续AEFI监测工作提供相应的指导。方法收集2019年平顶山市疫苗接种数据和AEFI数据,并以描述性流行病学的方式统计出平顶山市AEFI的分布特点。结果2019年平顶山市10个县(市)区共报告AEFI个案791例,其中一般反应749例(94.69%),排在前3位的疫苗分别为百白破疫苗(无细胞)、麻腮风疫苗、乙脑疫苗(减毒);异常反应40例(5.06%);偶合症2例(0.25%)。一般反应中常见发热、红肿、硬结,异常反应中常见过敏反应;AEFI病例以2岁以下儿童为主,共550例(69.53%);严重异常反应有热性惊厥、晕厥、血小板减少性紫癜、癫痫、卡介苗淋巴结炎。结论2019年平顶山市AEFI以一般反应为主,AEFI主要集中于鲁山县、叶县、卫东区3个地区,疫苗具有较高的安全性,需要提高AEFI监测系统的敏感性。
Objective To analyze the monitoring situation of suspected adverse events following immunization(AEFI)in Pingdingshan City in 2019,evaluate the safety of vaccination in Pingdingshan City and provide guidance for follow-up AEFI monitoring.Methods The vaccination data and AEFI data of Pingdingshan City in 2019 were collected,and the distribution characteristics of AEFI in Pingdingshan City were calculated by descriptive epidemiology.Results In 2019,a total of 791 AEFI cases were reported in 10 counties(districts)of Pingdingshan City,of which 749 cases(94.69%)were general reactions.The top 3 vaccines were DTaP(acellular)vaccine,MMR vaccine and JE vaccine(attenuated).There were 40 cases(5.06%)abnormal reaction and 2 cases(0.25%)of coincidental diseases.Fever/redness/swelling/induration are common in general reactions,and allergic reactions are common in abnormal reactions.The majority of AEFI cases were children under 2 years old with a total of 550 cases(69.53%).Severe abnormal reactions include febrile convulsion,syncope,thrombocytopenic purpura,epilepsy,BCG lymphadenitis.Conclusion In 2019,the AEFI cases in Pingdingshan City were mainly general reactions,and the AEFI cases were mainly concentrated in Lushan County,Ye County and Weidong District.Vaccines have high safety,and the sensitivity of the AEFI monitoring system should be improved.
作者
王晓明
徐蕊
尹笑然
WANG Xiaoming;XU Rui;YIN Xiaoran(Immunization Program Department,Pingdingshan Center for Disease Control and Prevention,Pingdingshan,Henan 467000,China)
出处
《生物医学工程学进展》
2025年第1期102-108,共7页
Progress in Biomedical Engineering
关键词
平顶山市
预防接种异常反应
监测
Pingdingshan City
Adverse Events Following Immunization(AEFI)
Monitor
