摘要
急性肾损伤越来越成为一种常见且日渐频繁的疾病。它由多种因素引起,包括缺血再灌注、肾毒性药物、脓毒症等,最终发展为慢性肾脏病和终末期肾病,而硫化氢(hydrogen sulfide,H_(2)S)作为继一氧化氮和一氧化碳之后的第三种内源性气体信号分子,在包括肾脏在内的几乎所有器官中都能合成。虽然关于H_(2)S调控肾脏生理和病理生理的研究尚处于起步阶段,但已有证据表明,在疾病状态下,肾脏细胞产生的H_(2)S减少,而H_(2)S供体则可改善肾损伤。具体而言,H_(2)S水平的异常与包括急性肾损伤在内的各种肾脏病理状况有关。本文综述了H_(2)S在急性肾损伤中的作用及研究进展,并探讨H_2S在肾脏疾病治疗领域的前景与挑战,为H_(2)S的临床应用提供新的思路。
Acute kidney injury is becoming a common and increasingly frequent disease.It is caused by a variety of factors,including ischemia reperfusion,nephrotoxic drugs and sepsis,eventually progresses to chronic kidney disease and end-stage kidney disease.Hydrogen sulfide(H2S)is the third endogenous gas signaling molecule secondary to nitric oxide and carbon monoxide that can be synthesized in almost all organs,including the kidney.Although research on the regulation of H2S in kidney physiol-ogy and pathophysiology is in its infancy,there is evidence that H_(2)S production by kidney cells is reduced in disease states and H_(2)S donors can ameliorate kidney damage.Specifically,abnormal H_(2)S levels have been associated with a variety of renal pathological conditions,including acute kidney injury.This article reviewed the role and research progress of H2S in acute kidney injury,and discussed the prospect and chal-lenge of H2S in the treatment of kidney disease,providing new ideas for clinical application of H_(2)S.
作者
贾宇韬
楼季庄
王晓燕
肖磊娟
Jia Yu-tao;Lou Ji-zhuang;Wang Xiao-yan;Xiao Lei-juan(Department of Nephrology,Nanjing BenQ Medical Center Affiliated to Nanjing Medical University,Nanjing 210019,China;The Core Laboratory for Clinical Research,Nanjing BenQ Medical Center Af-filiated to Nanjing Medical University,Nanjing 210019,China)
出处
《临床肾脏病杂志》
2025年第3期249-255,共7页
Journal Of Clinical Nephrology
基金
国家自然科学基金面上项目(81970605)
江苏省卫生健康委员会老年面上项目(LKM2022040)。
关键词
硫化氢
急性肾损伤
顺铂
缺血再灌注
脓毒症
Hydrogen sulfide
Acute kidney injury
Cisplatin
Ischemia reperfusion
Sepsis
