摘要
目的基于四维血流(4D Flow)MRI评估正常成年人横窦狭窄(TSS)程度与脑血流量的关系。方法该研究为横断面研究,前瞻性纳入2020年1月至2022年12月在首都医科大学附属北京友谊医院行磁共振静脉成像(MRV)及4D Flow MRI的81例正常志愿者。基于MRV评估横窦发育情况,分为发育不良组(26例)和无发育不良组(55例);测量狭窄处、远心端正常横窦面积,计算TSS程度和双侧横窦平均狭窄程度(BA-TSS)。分别以TSS程度=1/3、1/2、2/3为阈值判断TSS,分为无TSS组、单侧TSS组和双侧TSS组,分别为28、39、14例,37、37、7例和43、36、2例。基于4D Flow MRI测量颈内动脉、椎动脉、上矢状窦、直窦、横窦远心端及近心端的血流量,计算入脑血流量(双侧颈内动脉血流量+双侧椎动脉血流量)、回心血流量1(上矢状窦血流量+直窦血流量)、回心血流量2(双侧横窦远心端血流量之和)、回心血流量3(双侧横窦近心端血流量之和),并计算回心血流量/入脑血流量。采用独立样本t检验比较横窦发育不良组与无发育不良组间的差异;采用单因素方差分析比较无TSS组、单侧TSS组和双侧TSS组间差异。基于单因素的线性回归分析BA-TSS与血流量参数的关系。结果横窦发育不良组与无发育不良组间各血流量参数差异均无统计学意义(P均>0.05)。以1/3、1/2、2/3为阈值时,无TSS组、单侧TSS组、双侧TSS组间各血流量参数差异均无统计学意义(P均>0.05)。BA-TSS与入脑血流量呈线性正相关(β=0.986,95%CI 0.108~1.865,P=0.028),与回心血流量1、2、3均无线性相关性(P均>0.05)。BA-TSS程度与回心血流量1/入脑血流量(β=-0.001,95%CI-0.002~0,P=0.009)、回心血流量2/入脑血流量(β=-0.001,95%CI-0.002~0,P=0.018)呈线性负相关,与回心血流量3/入脑血流量无相关性(P=0.076)。结论正常成年人BA-TSS与入脑血流量呈正相关,与静脉窦回流占比呈负相关。
ObjectiveTo evaluate the relationship between transverse sinus stenosis(TSS)and cerebral blood flow in normal adults based on four-dimensional flow(4D Flow)MRI.MethodsThe study was a cross-sectional study.Totally 81 normal volunteers who underwent magnetic resonance venography(MRV)and 4D Flow MRI were prospectively enrolled at Beijing Friendship Hospital,Capital Medical University from January 2020 to December 2022.Based on MRV evaluation of transverse sinus dysplasia,the volunteers were divided into a dysplasia group(26 cases)and a non-dysplasia group(55 cases);The area of the stenosis and the normal transverse sinus at the distal end were measured.The degree of TSS and the bilateral average transverse sinus stenosis(BA-TSS)were calculated.TSS was determined using TSS levels of 1/3,1/2,and 2/3 as thresholds,and was divided into three groups:no TSS group,unilateral TSS group,and bilateral TSS group,with 28,39,and 14 cases,37,37,and 7 cases,and 43,36,and 2 cases,respectively.Based on 4D Flow MRI,the blood flow of the internal carotid artery,vertebral artery,superior sagittal sinus,straight sinus,and transverse sinus distal and proximal ends were measured.The cerebral blood flow(bilateral internal carotid artery blood flow+bilateral vertebral artery blood flow),venous sinus return blood flow 1(superior sagittal sinus blood flow+straight sinus blood flow),return blood flow 2(sum of bilateral transverse sinus distal end blood flow),return blood flow 3(sum of bilateral transverse sinus proximal end blood flow),and the ratio of return blood flow to cerebral blood flow were calculated.Independent sample t-test was used to compare the differences between the group with and without transverse sinus dysplasia;Single factor analysis of variance was used to compare the differences between the TSS free group,unilateral TSS group,and bilateral TSS group.Based on single factor linear regression,the relationships between BA-TSS and blood flow parameters were analyzed.ResultsThere was no statistically significant difference in various blood flow parameters between the group with and without transverse sinus dysplasia(all P>0.05).When using 1/3,1/2,and 2/3 as thresholds,there was no statistically significant difference in various blood flow parameters between the non TSS group,unilateral TSS group,and bilateral TSS group(all P>0.05).BA-TSS was linearly positively correlated with cerebral blood flow(β=0.986,95%CI 0.108-1.865,P=0.028),but not linearly correlated with return blood flow 1,2,and 3(all P>0.05).The degree of BA-TSS was linearly negatively correlated with return blood flow 1/cerebral blood flow(β=-0.001,95%CI-0.002-0,P=0.009)and return blood flow 2/cerebral blood flow(β=-0.001,95%CI-0.002-0,P=0.018),but not with return blood flow 3/cerebral blood flow(P=0.076).ConclusionThe BA-TSS degree in normal adults is positively correlated with cerebral blood inflow and negatively correlated with the proportion of venous sinus outflow.
作者
韩旭
丁贺宇
代驰航
仇晓妤
黄炎
汤若薇
龚树生
金龙
杨正汉
王振常
赵鹏飞
Han Xu;Ding Heyu;Dai Chihang;Qiu Xiaoyu;Huang Yan;Tang Ruowei;Gong Shusheng;Jin Long;Yang Zhenghan;Wang Zhenchang;Zhao Pengfei(Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Otolaryngology Head and Neck Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Interventional Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《中华放射学杂志》
北大核心
2025年第3期269-276,共8页
Chinese Journal of Radiology
基金
国家自然科学基金(82171886,61931013,82202098)
北京市自然科学基金(7222301)。
关键词
磁共振成像
四维血流
横窦
脑血流量
Magnetic resonance imaging
Four-dimensional flow
Transverse sinus
Cerebral blood flow
