摘要
非小细胞肺癌(NSCLC)是一种具有高发病率和高病死率的恶性肿瘤,临床治愈率低,且易出现治疗耐药。铁死亡是一种特殊的铁依赖的程序性死亡方式,已有研究证实铁死亡与NSCLC的发生发展密切相关,正逐渐成为NSCLC治疗的潜力靶点。中药在恶性肿瘤的防治中具有独特优势,多种中药单体、中药活性成分及中药复方可通过铁死亡途径抑制NSCLC进展。通过总结铁死亡的发生机制,挖掘铁死亡与NSCLC之间的关联,对近年来中药在诱导铁死亡拮抗NSCLC作用机制方面的研究进展进行综述,为中药防治NSCLC提供理论支持和治疗思路。
Non-small cell lung cancer(NSCLC)is a malignant tumor with high morbidity and mortality.The clinical cure rate is low,and the treatment resistance is easy to occur.Ferroptosis is a special iron-dependent programmed death.Studies have confirmed that ferroptosis is closely related to the occurrence and development of NSCLC,and ferroptosis is gradually becoming a potential target for the treatment of NSCLC.Traditional Chinese medicine(TCM)has unique advantages in the prevention and treatment of malignant tumors.A variety of TCM monomers,active ingredients and compounds can inhibit the progression of NSCLC through ferroptosis pathway.This article summarizes the mechanism of ferroptosis,explores the relationship between ferroptosis and NSCLC,and reviews the research progress of the mechanism of traditional Chinese medicine in inducing ferroptosis to antagonize NSCLC in recent years,so as to provide theoretical support and treatment ideas for the prevention and treatment of NSCLC with traditional Chinese medicine.
作者
张明蕊
范焕芳
陈佳琪
马盼
何芸
金明哲
杨柳
ZHANG Mingrui;FAN Huanfang;CHEN Jiaqi;MA Pan;HE Yun;JIN Mingzhe;YANG Liu(Hebei University of Chinese Medicine Graduate College,Shijiazhuang 050091,China;The First Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,China;Key Laboratory of Hebei Province Turbidity Toxin Syndrome,Shijiazhuang 050011,China)
出处
《陕西中医》
2025年第4期572-576,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
河北省自然科学基金资助项目(H2021423030)
河北省中医药管理局计划项目(2022332,2019024)。
关键词
非小细胞肺癌
中药
铁死亡
作用机制
耐药
恶性肿瘤
Non-small cell lung cancer
Traditional Chinese medicine
Ferroptosis
Action mechanism
Drug resistance
Malignant tumor
