摘要
目的:探讨经阴道彩色多普勒超声(阴超)参数联合血清鳞状细胞癌抗原(Squamous cell carcinoma antigen,SCCAg)水平检测对子宫内膜癌患者预后的预测价值。方法:回顾性收集我院2021年4月-2024年1月收治的91例子宫内膜癌患者为研究组,另根据1:1比例选取同期91例健康体检者为对照组;根据不同预后情况分为预后良好及预后不良患者;对比2组及不同预后患者入院时阴超参数[收缩期峰值流速(Peak systolic velocity,PSV)、搏动指数(Pulsatility index,PI)、阻力指数(Resistance index,RI)]及血清SCCAg水平,偏回归分析各指标水平与患者预后的关联性,并分析各指标联合检测对患者预后的预测价值及各指标不同水平患者发生预后不良的危险度。结果:研究组参数PSV及血清SCCAg水平显著高于对照组,参数RI、PI水平显著低于对照组(P<0.05);与预后良好患者相比,预后不良患者血清SCCAg参及数PSV水平显著升高、参数RI、PI水平显著低于预后良好患者(P<0.05);Logistic回归分析结果发现,参数RI、PI为患者发生预后不良的保护因素、血清SCCAg、PSV为患者发生预后不良的危险因素(P<0.05);入院时参数PSV、RI、PI及血清SCCAg水平联合预测预后不良的曲线下面积(Area under curve,AUC)为0.928,均高于各指标单独检测(P<0.05);入院时参数PSV及血清SCCAg高水平患者发生预后不良的危险度是低水平患者的2.171、2.695倍、参数RI、PI低水平患者发生预后不良的危险度是高水平患者的2.417、2.511倍(P<0.05);结论:阴超参数及血清SCCAg水平与子宫内膜癌患者预后相关,可作为评估子宫内膜癌预后的可靠指标,对早期预测子宫内膜癌患者预后具有较高的应用价值。
Objective:To investigate the predictive value of trans vaginal color Doppler ultrasound(vaginal ultrasound)parameters combined with serum squamous cell carcinoma antigen(SCCAg)level in the prognosis of patients with endometrial cancer;Methods:A total of 91 patients with endometrial cancer in our hospital from April 2021 to January 2024 were selected as a study group,and 91 healthy people were selected as a control group according to the ratio of 1:1;patients were divided into good prognosis and poor prognosis according to different prognosis;The vaginal ultrasound parameters[peak systolic velocity(PSV),pulsatility index(PI),resistance index(RI)]and serum SCCAg level at admission were compared between the two groups and patients with different prognosis.The correlation between the levels of each index and the prognosis of patients was analyzed by partial regression analysis.The predictive value of combined detection of each index for patients and the risk of poor prognosis in patients with different levels of each index were analyzed.Results:The parameters PSV and serum SCCAg level in the study group were significantly higher than those in the control group,and the levels of parameters RI and PI were significantly lower than those in the control group(P<0.05);compared with patients with good prognosis,the serum SCCAg and parameters PSV level in patients with poor prognosis were significantly higher,and the levels of parameters RI and PI were significantly lower than those in patients with good prognosis(P<0.05);Logistic regression analysis showed that parameters RI and PI were protective factors for poor prognosis,and serum SCCAg and PSV were risk factors for poor prognosis(P<0.05);the area under curve(AUC)of poor prognosis predicted by PSV,RI,PI and serum SCCAg level at admission was 0.928,which was higher than that detected by each index alone(P<0.05);the risk of poor prognosis in patients with high levels of parameter PSV and serum SCCAg at admission were 2.171 and 2.695 times than those of low levels,and the risk of poor prognosis in patients with low levels of parameter RI and PI were 2.417 and 2.511 times than those of high levels(P<0.05);Conclusion:The vaginal ultrasound parameters and serum SCCAg level are related to the prognosis of patients with endometrial cancer,which can be used as a reliable index to evaluate the prognosis of endometrial cancer,and have high application value for early prediction of the prognosis of patients with endometrial cancer.
作者
邓仝彤
崔智飞
肖四华
Deng Tong-tong;Cui Zhi-fei;Xiao Si-hua(Department of Ultrasound Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)
关键词
阴道彩色多普勒超声参数
鳞状细胞癌抗原
子宫内膜癌
预后
Vaginal color Doppler ultrasound parameters
Squamous cell carcinoma antigen
Endometrial cancer
Prognosis
