摘要
目的探讨3.0 T磁共振(MRI)T2 mapping序列联合血清新饱食分子蛋白1(nesfatin-1)水平对老年膝关节早期骨关节炎(OA)的诊断价值。方法选取2023年5月至2024年5月医院收治的膝关节OA的97例老年患者(OA组)和52例同期老年体检者(对照组),根据X线结果将膝关节OA组分为早期组和非早期组,均接受3.0T MRI T2 mapping序列扫描检测膝关节软骨区域T2值,检测血清nesfatin-1水平,比较上述指标差异并采用ROC曲线分析其对老年膝关节早期OA的诊断价值。结果97例老年膝关节OA患者中,早期组35例,非早期组62例,OA组患者膝关节5个软骨区域的T2值及nesfatin-1血清均高于对照组(P<0.05),早期组均低于非早期组(P<0.05);膝关节软骨区域T2值和血清nesfatin-1水平单独诊断早期OA的AUC在0.774~0.871范围,联合诊断的AUC为0.939。结论3.0 T磁共振T2 mapping序列联合血清nesfatin-1水平检测对老年膝关节早期OA具有较高的诊断价值。
Objective To investigate the diagnostic potential of combining 3.0T magnetic resonance imag-ing(MRI)T2 mapping sequences with serum nesfatin-1 levels for detecting early osteoarthritis(OA)in elderly knees.Methods 97 elderly patients with knee osteoarthritis(OA group)and 52 elderly individuals undergoing physical examinations(control group)were recruited from a hospital between May 2023 and May 2024.Based on X-ray findings,the OA group was further divided into an early-stage subgroup and a non-early-stage subgroup.All participants underwent 3.0T MRI T2 mapping sequence scans to measure the T2 values in the knee cartilage region,and serum nesfatin-1 levels were assessed.Differences in these indicators were compared between groups.Additionally,a receiver operating characteristic(ROC)curve was constructed to evaluate the diagnostic value of these parameters for early-stage knee OA in elderly individuals.Results Among 97 elderly patients with knee OA,35 cases were classified into the early-stage group,and 62 cases were categorized into the non-early-stage group.The T2 values in five cartilage regions of the knee and serum nesfatin-1 levels were significantly higher in the OA group compared to the control group(P<0.05).Moreover,these values were significantly lower in the early-stage group than in the non-early-stage group(P<0.05).The areas under the curve(AUC)for diagnosing early-stage OA using T2 values in knee cartilage regions and serum nesfatin-1 levels ranged from 0.774 to 0.871.Notably,the AUC for combined diagnosis reached 0.939(P<0.05).Conclusion 3.0T MRI using the T2 mapping sequence in combination with serum nesfatin-1 level detection demonstrates high diagnostic value for early OA in elderly patients with knee involvement.
作者
唐利
巩玉荣
曾立叶
高艳芳
邓成哲
TANG Li;GONG Yurong;ZENG Liye;GAO Yanfang;DENG Chengzhe(Physical Examination Center,Xingtai Medical College Second Affiliated Hospital,Xingtai 054000,Hebei,China;不详)
出处
《实用医学杂志》
北大核心
2025年第8期1238-1242,共5页
The Journal of Practical Medicine
基金
河北省医学科学研究课题计划项目(编号:20241818)
邢台市重点研发计划自筹项目(编号:2020ZC316)。
