摘要
[目的]探讨晚期卵巢上皮癌的临床病理特点及综合治疗对预后的作用。[方法]回顾性分析1995年1月～2001年12月该院收治的33例经手术病理证实的Ⅲ、Ⅳ期卵巢上皮癌。[结果]晚期卵巢上皮癌2年及5年生存率分别为44.18%和24.05%。5年生存率Ⅲ a 期100%、Ⅲ b 期28.81%、Ⅲc期16.05 %、Ⅳ期0;黏液性囊腺癌、透明细胞癌、混合性癌均为O ,浆液性囊腺癌29.34%、内膜样癌51.68% ;G1 为50.42%、G2 42.75 %、G32.53% ;术后残留癌灶<2cm5年生存率44.18%、≥2cm5年生存率4.75% ;术后化疗≥6个疗程的5年生存率47.56 %、<6个疗程的5年生存率3.89 %(P<0.01)。[结论]晚期卵巢上皮癌的预后与临床分期、病理类型、组织分级、术后残留癌灶大小及化疗疗程数相关 ,彻底的肿瘤细胞减灭术、正确的化疗可提高疗效 ,延长生存期。
To investigate the relationship between the clinicopathologic characteristics,comprehensive therapy and the prognosis in advanced epithelial ovarian cancer.From Jan .1995 to Dec.2001, 33 patients with advanced epithelial ovarian cancer in our hospital were analysed retrospectively.The 1_ and 5 year survival rates were 44.18% and 24.05% respectively. Stage Ⅲa(100%) had a better 5_year survival rate than Ⅲb(28.81%) and Ⅲc(16.05%) and Ⅳ(0). Prognosis in Clear cell carcinoma and mucinous adenocarcinoma and mixed tumor was poorer than those in serous and endometrioid adenocarcinoma. Grade1(50.42%) showed better survival rate than grade 2(42.75%) and grade 3(2.53%)(P <0.01) . Patients with residual tumor (<2cm) after primary operations had a better prognosis than those larger than 2cm. Patients with more than 6 courses postoperative chemotherapy showed higher 5 year survival rate than those less then 6 courses (47.56%vs.3.89%,P<0.01).[Conclusion] The prognosis of advanced epithelial ovarian cancer is related to FIGO substage , pathology, histologic grade. Optimal cytoreductive surgery with proper chemotherapy play important role for prognosis.
出处
《肿瘤学杂志》
CAS
2002年第6期340-342,共3页
Journal of Chinese Oncology
关键词
卵巢肿瘤
综合疗法
预后
ovarian neoplasms
comprehensive
prognosis.
