摘要
就个体而言 ,基因型是相对恒定的 ,也是先天具有的 ,而中医证候的表现是可变的 ,个体间存在着普遍性的较大差异 ,因此 ,同一疾病的证候具有多样性。但就总体而言 ,许多基因具有的多态性变化与某些疾病的发生有密切相关性 ,而某一病症的不同中医证候发生频率在一定范围内的分布则是相对稳定的 ,中医临床证候的多样性和复杂体系正好是基因多态性与临床表型多样性关系最好的研究对象。因此 ,我们推测 ,中医证候多样性及发生频率与特定基因多态性间可能存在某种关联 ,此种关联可能是证候形成与体质类型或先天禀赋关系的分子基础 ,也可为中医同病异治、异病同治等提供分子水平上的依据。
In regard to individual,genotype is inborn,oppositely constant,and the syndrome(“ZhengHou” in the Traditional Chinese Medicine) is variable,very characteristic;the syndrome in a disease has diversity owning to difference each other. However,in regard to total,many gene possess polymorphism associated with the development of certain disease,and the frequency distribution of the syndrome within the scope shows opposite stability.In the way,the complicated system and diversity of the syndrome become of best object of research on relationship between gene polymorphism and clinical phenotype of disease. Therefore,we suggest diversity and frequency of the syndrome may be associated with the frequency of particular alleles,which may be molecul basis on relationship between the syndrome formation and somatoplasm or endowment type. That provides an evidence on the numerator level for theory of “different therapeusis for the same disease,the same therapeusis for different disease” etc.On these grounds,this text further researches for possibility for role of apolipoprotein E gene polymorphism in the Phegm and Blood Stasis syndrome Differentiation of hyperlipoproteinemia or atherosclerosis. We hope that find a break for deeply developed foundation research in this aspect.
出处
《中国中医基础医学杂志》
CAS
CSCD
2002年第12期13-15,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家自然科学基金资助课题 (30171128)
关键词
基因多态性
痰瘀证候
载脂蛋白E
中医体质
相关性
Gene polymorphism
Phegm and Blood Stasis Syndrome
Apolipoprotein E
Somatoplasm of the Traditional Chinese Medicine
