摘要
目的 :探讨中药复方圣达欣抗肾间质纤维化的作用机制。方法 :采用大鼠单侧输尿管结扎模型 ,用圣达欣治疗 ,并设立假手术组、造模组、圣达欣高剂量组、圣达欣低剂量组。检测血清层粘连蛋白 (LN)、肿瘤坏死因子α(TNF -α)的含量 ,免疫组化法测肾脏组织转化生长因子 β1(TGF - β1)的表达并进行肾脏病理学观察。结果 :圣达欣能够降低血清中LN、TNFα水平 ,显著抑制TGF - β1的表达 ,减轻了肾小管间质的病理损伤。结论
Objective:To investigate effects of SDX on the process of renal interstitial fibrosis.Methods:The renal interstitial fibrosis rat model was established my unilatcral ureter ligature method. Fourty Wister rats were divided into four groups at random.Immunohistochemistry was applied to measured TGF-β 1 in the renal intertitium.LN、TNF-α were measured by different means.The pathologic changes was observed in the pathologic kidney by optical microscope.Results:SDX decreased the serum content of LN,TNF α,inhibit ede expression of TGF-β 1 remarkably and relievd the renal tubulointerstitial fibrosis.Conclusion:The results suggests that SDX can prevent the renal tubulointerstitial fibrosis.
出处
《中国中西医结合肾病杂志》
2003年第1期13-15,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
