摘要
目的:探讨外周血瘦素(leptin)水平与胰岛B细胞功能、胰岛素抵抗性(insulinresistance,IR)的关系。方法:检测45名正常糖耐量者、33例糖耐量减低者及36例新诊断的2型糖尿病患者的空腹血清瘦素水平,用30分钟特异胰岛素增值与血糖增值的比值(△SI30/△G30)评估胰岛B细胞初期时相胰岛素分泌功能,并应用稳态模型评估法(homeostasismodelassessment,HOMA)评估胰岛B细胞功能(HOMA-B)和胰岛素抵抗性(HOMA-IR),分析不同糖耐量者瘦素水平与胰岛B细胞功能、胰岛素抵抗性的关系。结果:不同糖耐量者的瘦素水平比较无统计学差异;瘦素与性别和体重指数在3组中均呈正相关(r=0.348～0.661,均为P<0.01);瘦素与△SI30/△G30、HOMA-B和HOMA-IR只在2型糖尿病组呈正相关(r=0.321～0.348,均为P<0.05)。结论:不同糖耐量者的血瘦素水平比较无统计学差异;不同糖耐量者的血瘦素水平均与性别和体重指数呈正相关;仅2型糖尿病患者的血瘦素水平与胰岛B细胞功能和胰岛素抵抗性呈正相关。
Objective:To investigate the relationship between fasting serum leptin levels (leptin) and pancreatic islet B cell function,insulin resistance. Methods:Fasting serum leptin were measured in 45 subjects with normal glucose tolerance (NGT),33 with glucose intolerance (IGT) and 36 newly diagnosed type 2 diabetics. The ratio of the increased value of 30 minutes specific insulin (SI) and blood glucose (G) was used to assess initial stage pancreatic islet B cell function,and homeostasis model assessment (HOMA) was used to estimate the pancreatic islet B cell function (HOMA B) and insulin resistance (HOMA IR). Results:There were no significant differences in leptin among groups with different glucose tolerance; The correlations of leptin with sex and body mass index (BMI) were all positive in 3 groups (r=0.348～0.661,P<0.01);The correlations of leptin with △SI30/△G30,HOMA B and HOMA IR were positive only in newly diagnosed type 2 diabetics group (r=0.321～0.348,P<0.05). Conclusion:There are no significant differences in leptin levels among individuals with different glucose tolerance. Leptin is positively correlated with sex and BMI in 3 groups; leptin is positively correlated with B cell function and insulin resistance only in DM group.
出处
《新医学》
北大核心
2003年第2期74-76,共3页
Journal of New Medicine
基金
广东省自然科学基金资助项目(980117)
关键词
血清
瘦素
胰岛B细胞功能
胰岛素抵抗
2型糖尿病
糖耐量
Leptin Pancreatic islet B cell function Insulin resistance Type 2 diabetics Glucose tolerance
