摘要
目的 观察Nogo在成年大鼠三叉神经节、背根节及腰段脊髓中的分布 ,探讨其存在的意义。 方法 采用抗Nogo(N 18)多克隆抗体免疫组织化学SP法。 结果 成年大鼠三叉神经节、背根节感觉神经元胞浆和胞核以及腰段脊髓灰质神经元胞核内出现Nogo免疫反应。 结论 Nogo免疫反应存在于大鼠三叉神经节、背根节感觉神经元胞浆和胞核以及腰段脊髓灰质神经元胞核内 ,应重新认识Nogo的功能。
Objective In order to observe the localization of Nogo(N\|18) in the trigeminal ganglion,dorsal root ganglion and lumbar spinal cord of adult rat as well as to discuss the significance of Nogo(N\|18) expression. Methods Nogo(N\|18) antiserum immunohistochemical SP staining technique was used in present study. Results It was found that the positive Nogo(N\|18) immunoreactivity was present in the sensory neurons of trigeminal ganglion and dorsal root ganglion as well as in the neurons of the lumbar spinal cord gray matter of adult rat.Conclusion\ High levels of Nogo(N\|18) expression were found in neurons,raising important questions abount the function of neuronal Nogo
出处
《解剖学报》
CAS
CSCD
北大核心
2003年第1期32-35,共4页
Acta Anatomica Sinica
基金
全军"十五"医学科研基金杰出人才项目 (0 1J0 18)
关键词
表达
NOGO
三叉神经节
背根节
脊髓
免疫组织化学
大鼠
Expression
Nogo
Trigeminal ganglion
Dorsal root ganglion
Spinal cord
Immunohistochemistry
Rat
