摘要
对药物从亲水聚合物凝胶系统中释放的机理进行了研究。建立了药物释放的数学模型。同时考虑溶剂渗透引起材料松弛膨胀 ,在模型中引入了反映应力应变关系的弹性体方程。用摄动方法对方程进行了求解。同时利用溶胀界面数和扩散德伯拉数 ,对不同机理控制下的介质移动过程和药物释放过程 。
The mechanism of drug release from swellable polymer was studied. The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelastic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release, especially relax controlled mechanism.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2003年第1期17-21,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 ( 2 990 40 0 3)
