摘要
目的探讨糖尿病肾病中血清胱抑素C(Cys-C)、肾小球滤过率(e-GFR)、尿微量白蛋白与肌酐比值(m-Alb/Cr)的相关关系。方法对121例糖尿病肾病患者及60例正常对照组人群进行血清胱抑素C、肾小球滤过率、尿微量白蛋白与肌酐比值检测,并按不同血清胱抑素C水平分组,比较血清胱抑素C、肾小球滤过率、尿微量白蛋白与肌酐比值的敏感性与相关性。结果糖尿病肾病组与正常对照组之间血清胱抑素C水平存在显著性差异(p【0.05);在不同的胱抑素C分组中,糖尿病肾病A组尿m-Alb/Cr与正常对照组存在显著性差异(p【0.05),而糖尿病肾病B组与糖尿病肾病A组及正常对照组间比较Cys-C、e-GFR、m-Alb/Cr三指标间均存在显著性差异(p【0.01);胱抑素C在e-GFR异常时,两者具有很好的相关性。结论糖尿病肾病中尿m-Alb/Cr敏感性明显高于血清Cys-C及e-GFR;血清胱抑素C在e-GFR异常时存在明显相关性,胱抑素C在糖尿病肾病的病程监控中具有很好的应用价值。
Objective To investigate the correlation of diabetic nephropathy serum cystatin C(Cys-C),and glomerular filtration rate(e-GFR),urinary albumin creatinine ratio(m-Alb/Cr).Methods Detect 121 cases of diabetic nephropathy patients and 60 normal controls for serum cystatin C,glomerular filtration rate,urinary albumin creatinine ratio,according to different levels of serum cystatin C group,compare the serum cystatin C,glomerular filtration rate,urinary albumin creatinine ratio sensitivity and relativity.Results In diabetic nephropathy group and the normal control group,the level of serum cystatin C showed significant differences(p<0.05);cystatin C in different groups,the diabetic nephropathy group A and the normal control group,urinary m-Alb/Cr had significant differences(p<0.05),diabetic nephropathy group B group and control group A between the Cys-C,e-GFR,m-Alb/Cr three indexes were significantly different(p<0.01);cystatin C while e-GFR abnormal,with a good correlation between the two.Conclusion The sensitivity of urine m-Alb/Cr was significantly higher than serum Cys-C and e-GFR in diabetic nephropathy;serum cystatin C while e-GFR abnormal exist obvious correlated,cystatin C in the course of prosecution of diabetic nephropathy has a very good value.
出处
《浙江检验医学》
2012年第2期45-47,共3页
Zhejiang Journal of Laboratory Medicine
