摘要
目的 观察病人体温对国产维库溴铵体内清除过程的影响。方法 选择ASA分级I～Ⅱ级行择期手术患者68例病人随机分为两组:I组为保温组(36例),Ⅱ组为未保温组(32例)。用加速度仪监测神经肌肉传导功能,观察两组病人体温与国产维库溴铵作用高峰时间、临床作用时间、体内作用时间、恢复时间值的差别,并对病人体温与肌松药体内清除各时相值进行单因素相关分析。结果与I组比较,Ⅱ组的病人体温明显降低,肌松药总用量明显减少,肌松药的高峰时间、临床作用时间、体内作用时间、恢复时间均明显延长(P<0.05)。病人体温与肌松药高峰时间、临床作用时间、体内作用时间、恢复时间值间有明显的相关性,相关系数分别为-0.62、-0.73、-0.67、-0.71,P均<0.01。结论低体温影响国产维库溴铵的体内清除过程,延长其作用时间。
Objective To investigate the influence of body temperature on the recovery from vecuronium-induced neuromuscular block.Methods Sixty-eight ASA I - II patients (39 male, 29 female) aged 19-69 yr undergoing elective surgery under general anesthesia were randomly divided into 2 groups: group I in which patients' body temperature was maintained at 37 ℃ using warming blanket; group II in which no measures were taken to maintain the patients' body temperature. The patients were premedicated with phenobarbital 2 mg·kg-1 and atropine 0.01 mg· kg-1 intramuscularly. Anesthesia was induced with fentanyl 5 μg· kg -1, propofol 2 mg· kg-1 and vecuronium 0. 1 mg·kg-1 . After tracheal intubation anesthesia was maintained with inhalation of 0.8%-2.5% isoflurane and propofol infusion at a rate of 2-4 mg · kg-1· h-1 .Neuromuscular block was monitored using accelograph (Biometer, Denmark) .The changes in TOF and T1 were monitored. T1was maintained at 10% by vecuronium infusion during operation. At the end of operation a bolus of vecuronium 80μg · kg-1 was given intravenously and T1 was completely depressed. The time for T1 to returned to 5% ,25% and 90% and the time required for T1 to return from 25 % to 75 % were recorded. The total amount of vecuronium given was recorded. Temperature probe was placed in the esophagus ( core temperature) . The room temperature was also recorded. Results The body temperature was lower, the total dose of vecuronium was smaller and the vecuronium-induced neuromuscular block lasted longer in group II as compared with group I . There was close correlation between body temperature and vecuronium-induced neuromuscular block. Conclusions Lower core body temperature could prolong the vecuronium-induced neuromuscular block.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2003年第3期182-184,共3页
Chinese Journal of Anesthesiology
关键词
体温
维库溴铵
体内清除
剂量效应关系
肌松药
Vecuronium Bromide
Dose-response relationship,drug
Body temperature
