摘要
目的 :观察羟基喜树碱 (HCPT)加醛氢叶酸 (CF)加 5 -氟脲嘧啶 (5 - Fu)方案治疗晚期大肠癌的疗效与毒副作用。方法 :1999年 7月～ 2 0 0 2年 5月我科收治晚期大肠癌 6 8例 ,随机分为两组 ,各 34例。治疗组予以 HCPT加 CF加 5 - Fu化疗 ;对照组予以 CF加 5 - Fu化疗。结果 :治疗组有效率为 5 2 .9% ,其中完全缓解 2例 ;对照组有效率为 32 .4 % ,两组比较差异有显著性意义 (P <0 .0 5 )。治疗组的白细胞下降 4 1.0 % ,高于对照组的 2 6 .5 % ,差异有显著性意义 (P <0 .0 5 ) ,但其下降分度 5 7.1%为 度。结论 :HCPT加 CF加 5 - Fu方案能显著提高晚期大肠癌化疗的有效率 。
Objective: To evaluate the efficacy and toxicity of CF/5 Fu plus hydroxy camptothecin on advanced colon cancer. Methods: Sixty eight cases advanced colon cancer were randomly divided into two groups: the treatment group offered hydroxy camptothecin plus CF/5 Fu, and the control group offered CF/5 Fu. Results: The overall effective rate of the treatment group was 52.9% and that of the control group 32.4%. There was significant difference between them (P<0.05). The incidence of leucopenia of the treatment group was higher than that of the control group. The difference between them was significant (P<0.05). Conclusion: CF/5 Fu plus hydroxy camptothecin can greatly improve the efficacy of chemical therapy on patients with advanced colon cancer with tolerable toxicity.
出处
《中国中西医结合消化杂志》
CAS
2003年第2期98-99,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
结肠肿瘤
羟基喜树碱
cancer, colon
hydroxy camptothecin
