摘要
目的 了解不同甲状腺功能患者血浆总同型半胱氨酸水平 ,探讨其与甲状腺功能的相关性。方法 收集 12例甲状腺功能减退 (甲减 )患者、2 8例甲状腺功能亢进 (甲亢 )患者及 30例正常体检人群的血浆 ,用高效液相色谱法测定总同型半胱氨酸水平 ,用放射免疫法测定叶酸和VitB12 ,酶法测定胆固醇。结果 甲减组总同型半胱氨酸和胆固醇水平较正常对照组显著升高 (P<0 .0 1) ,甲减组叶酸水平较正常对照组降低 (P <0 .0 1) ;甲亢组总同型半胱氨酸和胆固醇水平较正常对照组降低 (P <0 .0 1) ,叶酸水平在此两组间无显著性差异 (P >0 .0 5 ) ;甲减组总同型半胱氨酸较甲亢组显著升高 (P <0 .0 1) ,甲减组胆固醇水平较甲亢组显著升高 (P <0 .0 1) ,甲减组叶酸水平较甲亢组显著降低 (P <0 .0 1) ;三组间VitB12 水平均无显著性差异 (P >0 .0 5 )。不同甲状腺功能人群血浆总同型半胱氨酸与其游离T4 呈负相关。结论 血浆总同型半胱氨酸水平可能对判断甲状腺功能有辅助作用 ,甲减患者高同型半胱氨酸血症是其易患心血管疾病的一个独立危险因素。
Objective To determine the possible relationship between plasma homocysteine and thyroid function. Methods Plasma homocysteince from 12 hypothyroid patients,28 hyperthyroid patients and 30 normal persons(as control group) were measured with high performance liquid chromatography, folate and vitamin B12 were measured with radioimmunoassay,and cholesterol were measured with enzyme assay. Results The levels of plasma homocysteine and cholesterol of hypothyroid group were much higher than that of control group(P<0.01),the folate level of hypothyroid group was much lower than that of control group(P<0.01);the levels of plasma homocysteine and cholesterol of hyperthyroid group were much lower than that of control group(P<0.01),there was no statistical difference in folate level between the two groups(P>0.05);the levels of plasma homocysteine and cholesterol of hypothyroid group were significantly higher than that of hypothyroid group(P<0.01),the folate level in hypothyroid was significantly lower than that of hyperthyroid group(P<0.01); there was no statistical difference in VitB 12level among the three groups(P>0.05). The levels of plasma homocysteine and cholesterol have negative correlation to plasma free T 4.Conclusion The level of plasma homocysteine may be a useful mark to judge thyroid function. High homosystienamia in hypothyroid patient is an independent risk factor of cardio-vascular disease.
出处
《临床内科杂志》
CAS
北大核心
2003年第2期96-98,共3页
Journal of Clinical Internal Medicine
