摘要
目的 了解产超广谱 β 内酰胺酶 (ESBLs)细菌感染的发病情况 ,加强监控 ,防止感染的暴发。方法 分析了我院 2 0 0 0～ 2 0 0 1年间由产ESBLs细菌引起院内感染因素。结果 2 0 0 0～ 2 0 0 1年间由产ESBLs细菌引起医院感染共 35株 ,多见于肺炎克雷伯菌 17株占 4 8 5 7% ,大肠埃希菌 9株占 2 5 71% ,阴沟肠杆菌 8株占 2 2 86 % ,粘质沙雷菌 1株 ,占 2 86 % ,研究发现 ,入住ICU病房先期使用三代头孢菌素及长期住院与此菌感染密切相关。结论 产ESBLs细菌发生的院内感染日益增多 ,多见于长期住院、入住ICU病房 ,先期使用三代头孢菌素 ,免疫功能低下患者中 ,广泛开展超广谱 β 内酰胺酶的测定 ,隔离ESBLs感染患者 ,严格执行消毒隔离措施 ,严格控制广谱抗生素的应用 ,是预防和控制ESBLs细菌感染的重要措施。
OBJECTIVE To investigate prevalence of extended spectrum β lactamase(ESBLs) producing bacteria and to prevent their outbreak. METHODS Thirty five cases of nosocomial infection by positive ESBLs bacteria were studied in our hospital from 2000 to 2001 and the caused pathogens of nosocomial infection were analysed, their were 17 strains of Klebsiella pneumoniae (25 71%), 9 strains of Escherichia coli (26%), 8 strains of Enterobacter cloacae (22 86%) and 1 strain of Serratia marcescens (2 86%). RESULTS The study shows, the positive rate of ESBLs producing in ICU hospitalization longly. using third generation cephalosporins early and the decrease in immunriy was more significant. CONCLUSIONS The common reason of nosocomial infection of (ESBLs) producing bacteria is long time hospitalization, using third generation cephalosporions earlier in ICU and the decrease in immunity. The surveillance for the bacteria should be performed widely. The isolation and control of use of antibiotics should be performed strictly in patients with positive ESBLs bacteria. It is the important way to prevent and control the infection of the ESBLs bacteria.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第2期180-181,共2页
Chinese Journal of Nosocomiology
