摘要
目的 :观察以益气活血、通脉止痛组成的中药复方制剂芪丹通脉片 (QDTMT)对缺血性心脏病患者和实验性急性心肌缺血犬的血液流变学行为的影响 .方法 :临床选择符合WHO制定的缺血性心脏病的命名及诊断标准患者 ,口服QDTMT 4片 ,3次·d-1,1mo为 1疗程 ,采用自身对照 ,检测治疗前后冠心病心绞痛患者的血液流变学指标 .采用结扎冠状动脉 ,造成犬急性心肌缺血模型 ,经十二指肠灌入实验药物 ,从实验犬心大静脉留取血样 ,检测急性心肌缺血犬实验条件下的血液流变学指标 .结果 :该中药制剂能降低冠心病心绞痛患者及实验性急性心肌缺血犬的全血高切 (ηbh)粘度 (6 .7±0 .4与 7.3± 0 .4 ;5 .3± 0 .2与 6 .7± 0 .9)、低切 (ηb1)粘度 (2 1.4± 1.4与 2 3.7± 2 .5 ;15 .2± 0 .3与 2 1.0± 4 .1)、血浆粘度 (ηp)(1.75± 0 .0 4与 1.81± 0 .0 8;1.5 3± 0 .0 3与 1.6 9± 0 .0 3)和加快红细胞电泳时间 (EET) (18.3± 0 .1与 19.0± 0 .6 ) ,与对照组比较有显著差异 (P <0 .0 5 ,P <0 .0 1) .结论 :QDTMT对冠心病心绞痛患者及实验性急性心肌缺血犬血液高粘滞综合征的血液流变学行为有改善作用 .
AIM: To study the effects of Qidantongmai tablet (QDTMT) on the hemorrheology of both patients and experimental dogs with myocardial ischemia. METHODS: Patients with myocardial ischemia were given QDTMT, 4 tablets, 3 time per day for 1 month and hemorrheological indexes were measured before and after therapy. Coronary artery ligation was employed to establish a myocardial ischemia model with canine. Coronary sinus cannula was inserted through the external jugular vein and QDTMT was duodenally perfused. Hemorrheological indexes were measured before and after the ligation. RESULTS: In comparison with those of the control, hemorrheological indexes such as whole blood high-and low-shear viscosity (6.7±0.4 vs 7.3±0.4; 5.3±0.2 vs 6.7±0.9 ), (21.4±1.4 vs 23.7±2.5; 15.2±0.3 vs 21.0±4.1 ), plasma viscosity (1.75 ±0.04 vs 1.81±0.08;1.53±0.03 vs 1.69±0.03) and erythrocyte eletrophoretic time (EET) (18.3±0.1 vs 19.0±0.6) reduced significantly in both patients and canines with myocardial ischemia ( P<0.05, P < 0.01). CONCLUSION: QDTMT can improve the hemodynamics of both patients and experimental canines with myocardial ischemia.
出处
《第四军医大学学报》
北大核心
2003年第5期394-396,共3页
Journal of the Fourth Military Medical University
基金
军队新药研究重点项目 (1 9980 1 1 8)
