冠心病患者血清血管内皮生长因子水平与冠状动脉病变程度的关系被引量：28

Correlation between serum level of vascular endothelial growth factor and severity of coronary artery stenosis in patients with coronary heart disease

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摘要目的 :探讨冠心病 (CHD)患者血清血管内皮生长因子 (VEGF)水平与冠状动脉病变的关系。方法 :采用酶联免疫吸附法 (ELISA)检测了 12 4例经冠状动脉造影证实有一支以上主要冠状动脉狭窄≥ 5 0 %的CHD患者血清VEGF水平 ,并作相关分析。结果 :CHD组血清VEGF水平明显高于正常对照组〔(2 93.2± 12 6 .3)ng/L∶(12 0 .1± 31.5 )ng/L ,P <0 .0 1〕 ,双支和三支血管病变患者血清VEGF水平高于单支组〔(2 83.4± 85 .0 )ng/L ,(398.1± 10 5 .5 )ng/L∶ (191.7± 2 7.3)ng/L ,P <0 .0 1〕 ,随着血管狭窄程度的加重 ,血清VEGF水平升高越明显 ,两者呈显著正相关 (r =0 .78,P <0 .0 0 1) ,CHD并发高血压和 (或 )糖尿病对血清VEGF水平无显著影响 (P >0 .0 5 )。结论 :CHD患者血清VEGF水平升高。 Objective:To investigate the correlation between serum level of vascular endothelial growth factor(VEGF) and the severity of coronary artery stenosis in patients with coronary heart disease( CHD). Methods:Serum level of VEGF in 124 CHD patients were measuneal and compared with that of 90 normal control subjects.Results:The serum levels of in VEGF in CHD patients were significantly elevated as compared with that of control subjects〔( 293.2 ± 126.3 )ng/L vs( 120.1 ± 31.5 )ng/L, P< 0.01 〕. Among CHD group, patients with stenosis lesion in 2 or 3 branches of coronary artery had higher VEGF level〔( 283.4 ± 85.0 )ng/L,( 398.1 ± 105.5 )ng/L Vs ( 191.7 ± 27.3 )ng/L, P< 0.01 〕, and serum VEGF concentration were positively correlated with the severity of coronary artery stenosis(r= 0.78 , P< 0.001 ). Conclusion:Serum levels of VEGF in patients with CHD are elevated, it reflects the severity of coronary artery disease.

作者韦方耿庆山周钢符永恒谭红红余细勇

机构地区贵州省人民医院心内科广东省心血管病医院心内科广东省心血管病研究所分子药理室

出处《临床心血管病杂志》 CAS CSCD 北大核心 2003年第3期132-133,共2页 Journal of Clinical Cardiology

关键词冠心病冠状动脉疾病血管内皮生长因子病理 Coronary disease Vascular endothelial growth factor

分类号 R541.402 [医药卫生—心血管疾病]

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