摘要
目的:探讨新辅助化疗前后同一大肠癌患者微血管密度(MVD)有否变化及其与预后的关系。方法:选择确诊为大肠癌的患者28例为观察组,分别检测同一患者经动脉新辅助化疗前后MVD。同期设未行治疗的大肠癌患者25例为对照组。结果:观察组患者MVD有明显变化,统计学检验P<0.05,有显著性差异。对照组患者其MVD无明显变化。新辅助化疗后患者3年内复发6例,对照组3年内复发13例。复发者其MVD明显高于未复发者,经统计学检验P<0.05,有显著性差异。结论:新辅助化疗前后同一大肠癌患者MVD有明显变化.提示新辅助化疗可以降低MVD;新辅助化疗后患者3年内复发率明显低于未行术前化疗的同期大肠癌患者。提示新辅助化疗后降低肿瘤患者术后复发率与MVD减少有关,对于估计肿瘤患者的预后及指导临床治疗具有重要意义。
Purpose: To investigate whether uhere are changing of MVD in the same patient of large intestine cancer following new supplementary chemotherapy and their relationship with prognosis. Methods: The MVD expression of the same patients have been examined seperately by new supplementary chemotherapy treatment in 28 patients with large intestine cancer, while 25 patients with large intestine cancer without treatment as control. Results: There are significantly different expression of MVD in the same large intestine cancer between treatment and no treatment. The statistics date is P < 0.05. In the test group,6 cases have recurred in three years, meanwhile 13 cases in control group.The reured patients had higher MVD degree experssion than no reaored patieats(P <0.05) . Conclusions:The MVD degree of large intestine cancer can be decreased by new supplementary chemotherapy.The result is very important for estimate and direct clinical treatment in large intestine cancer. New supplementary chemotherapy can decrease the recuming rate of large intestine cancer,it is just relation to the reduce of MVD degree.
出处
《临床消化病杂志》
2003年第2期51-52,共2页
Chinese Journal of Clinical Gastroenterology
关键词
大肠癌
辅助化疗
微血管密度
预后
MVD
Large intestine cancer New supplementary chemotherapy Microvessel density Prognosis.
