摘要
研究表明加巴喷丁 (gabapentin)可作用于脊髓背角神经原突触后钙离子通道 ,从而可能阻断了神经病理性疼痛产生的过程。临床证实加巴喷丁对糖尿病神经病变和带状疱疹后神经痛的治疗效果 。
Gabapentin may bind the α 2δ subunit of the voltage -dependent calcium ion channels at the postsynaptic dorsal horn and interrupt t he series of events possibly leading to the experience of a neuropathic pain sen sation. Many clinical studies have clearly demonstrated the efficacy of gabapent in in the treatment of diabetic neuropathy and postherpetic neuralgia. Gabapenti n is considered an effective drug with its minimal side effects and drug interac tions in the management of neuropathic pain syndromes.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第3期241-244,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
