摘要
目的 :探讨肿瘤转移抑制相关基因表达水平与胃癌生物学行为的关系。方法 :采用免疫组织化学LSAB法分析nm2 3 NDPK在胃癌的表达及其与多种指标的关系。结果 :nm2 3 NDPK表达强度随肿瘤临床分期和病理分级的增高而增高。高分化肿瘤nm2 3 NDPK的表达明显低于中、低分化肿瘤 ,有淋巴结转移者nm2 3 NDPK的表达显著低于未转移者。结论 :nm2 3 NDPK可能在胃癌的发生及转移中起不同的调节作用 ,可作为评价胃癌恶性程度、肿瘤进展及预后的指标。
Objective: The expression of nm23 genes/NDPK was studied in order to evaluate its clinical significance.Methods: The expression of nm23/NDPK genes was examined and several parameters of gastric carcinoma were analyzed.Results: The expressive intensity of nm23 genes/NDPK was associated with the stages and the grading of the tumor.Positive rates in the well differentiated gastric carcinoma were lower than those of moderately and poorly differentiated.Expression rate in patients with lymphatic metastasis was lower.Conclusion: nm23/NDPK might exert varied modulating actions on the genesis and metastasis of gastric carcinoma.Therefore,it may serve as a parameter to judge malignancy,progression and prognosis.
出处
《山西职工医学院学报》
CAS
2003年第2期1-3,共3页
Journal of Shanxi Medical College for Continuing Education
