摘要
目的探讨颅脑损伤后血清TNF-α和IL-6的表达及对预后的影响。方法采用双抗体夹心ABC-ELISA方法,检测颅脑损伤后血清中TNF-α和IL-6的含量,比较颅脑损伤分级与血清中TNF-α和IL-6含量之间的关系以及外伤后的变化趋势,并探讨其对临床预后的影响。结果重型颅脑损伤后血清TNF-α和IL-6明显升高,在不同时间轻型、中型颅脑损伤组对比有明显差异(P<0.01)。结论血清中TNF-α和IL-6表达在重型颅脑损伤中明显增高,与颅脑损伤轻重成正比,并与预后密切相关。
Objective To explore the expressions of TNF-醓nd IL-6in serum and their effe ct to the prognosis after head injury.Methods The ABC-ELISA method of double antibody with filling was adopted in this research to check the contents of TNF-醓nd IL-6in serum after craniocerebral trauma,the relationship between the grading of craniocerebral trauma and the contents of TNF-醓nd IL-6in serum ,and their influence on the prognosis were studied.Results It was discovered t hat the contents of TNF-醓nd IL-6obviously in-creased after serious cranioc erebral trauma and there were significant differences between the serious cran iocerebral trauma and the minor,moderate craniocerebral traumas in different periods(P<0.01).Conclusion The expressions of TNF-醓nd IL-6in serum are obviously higher in serious craniocerebral trauma and are positively correl ated with the severity of craniocerebral trauma and prognosis.
出处
《浙江创伤外科》
2003年第3期143-145,147,共4页
Zhejiang Journal of Traumatic Surgery
