摘要
目的 探讨失血性低血容量休克病人血浆一氧化氮 (NO)浓度与预后的关系。方法 2 0 0 1年 7月至2 0 0 2年 1月 ,应用比色法测定 2 9例失血性低血容量休克病人血浆NO浓度 ,与 2 0例择期手术病人进行对照 ,观察NO与多器官功能障碍综合征 (MODS)的关系。结果 休克组血浆NO浓度 ( 74 2± 46 9) μmol/L ,较对照组( 5 0 5± 2 3 3 ) μmol/L明显升高 (P <0 0 5 )。休克组发生MODS病人血浆NO浓度 ( 90 4± 5 3 5 ) μmol/L ,较未发生MODS者血浆NO浓度 ( 5 4 2± 2 7 9) μmol/L明显升高 (P <0 0 5 )。
Objective To investigate the relationship between the plasma levels of nitric oxide (NO) and prognosis of hemorrhagic hypovolemic shock. Methods The plasma levels of NO were measured by colorimetric assay in 29 hemorrhagic hypovolemic shock patients hospitalized from July 2001 to Jan 2002, and another 20 patients for selective operation served as control group. The relationship between plasma levels of NO and multiple organ dysfunction syndrome (MODS) was analyzed. Results The plasma levels of NO were significantly higher in hemorrhagic shock group[(74 2±46 9)μmol/L] than that of control group[(50 5±23 3)μmol/L](P<0 05).The plasma levels of NO were higher in MODS group[(90 4±53 5)μmol/L] than that of non-MODS group[(54 2±27 9)μmol/L](P<0 05).Conclusion The overproduction of nitric oxide may contribute to the development of MODS after hemorrhagic hypovolemic shock.
出处
《中国实用外科杂志》
CSCD
北大核心
2003年第6期355-357,共3页
Chinese Journal of Practical Surgery
关键词
血浆
一氧化氮
浓度
失血性低血容量休克
MODS
Hemorrhagic hypovolemic shock Multiple organ dysfunction syndrome Nitric oxide
