摘要
目的 :通过对抗癫痫药物血药浓度监测结果分析 ,为临床提高本类药物的治疗水平作参考。方法 :采用荧光偏振免疫法对 2 6例服用苯妥英钠、74例服用卡马西平、14 4例服用丙戊酸钠的患者血药浓度监测结果及临床疗效分析、评价。结果 :本类药物治疗指数小 ,安全度较低 ,其作用的个体差异大。结论 :癫痫患者应重视血药浓度监测 ,并结合其他因素调整用药方案 ,以达到安全、有效、合理应用本类药物。
Objective: To give some information for rational administration of oral antiepileptic drugs for epileptic patients in clinic by analyzing the results of therapeutical drug monitoring of antieleptic drugs.Method: The serum concentration of oral phenytoin, carbamazepine and valproic acid were determined in 26,74 and 144 epileptic patients by fluorescence polarization immunoassay, respectively.Result: The effective concentration of the three kinds of antiepileptic drugs varied in different patients.Conclusion: The administration of oral antiepileptic drugs for epileptic patients must be based on the data of drug concentration in serum. The other factors must be also considered.
出处
《中国药师》
CAS
2003年第8期485-486,共2页
China Pharmacist
关键词
抗癫痫药
血药浓度监测
分析
Antiepileptic drugs
Serum concentration monitoring
Analysis
