摘要
目的 探讨新生儿高胆红素血症患儿脑损伤的早期预测方法。 方法 对 38例高胆患儿分别进行新生儿神经行为评分 (NBNA)和脑干听觉诱发电位 (BAEP)检测。 结果 高胆组BAEP异常率明显高于对照组 (P <0 0 1) ,Ⅰ、Ⅴ波潜伏期与对照组比较差异显著 (P <0 0 1,P <0 0 5 )。高胆组NBNA评分明显低于对照组 (P <0 0 0 1) ,主要失分项目为行为能力和主动肌张力。在血清胆红素≥ 2 0 4μmol/L时 ,胆红素水平与NBNA评分呈显著负相关 (P <0 0 1) ,血清胆红素浓度≤ 2 5 6 5 μmol/L时 ,部分高胆患儿NBNA评分即有降低 ,BAEP异常率增高 ,黄疸消退后NBNA评分全部恢复正常。 结论 NBNA和BAEP是早期诊断新生儿胆红素脑病敏感而有效的方法 ,有助于判断病情及指导治疗。
Objective To find out the early prediction methods for neonatal brain damage with hyperbilirubinemia.Methods Neonatal behavioral neurological assessment (NBNA) and brainstem auditory evoked potential (BAEP) were measured in 38 neonates with hyperbilirubinemia.Results BAEP was higher in neonatal hyperbilirubinemia group than the control group (P<0\^01).There was differences obviously in Ⅰ and Ⅴ waves of the two groups (respectively P<0\^01,P<0\^05).Main causes of low NBNA was behavior ability and active muscle tension.There was negative correlation between value of serum bilirubin and NBNA (P<0\^01) when serum bilirubin ≥204 μmol/L.When level of serum bilirubin ≤256\^5 μmol/L. NBNA of part neonates with hyperbilirubinemia went down and BAEP was abnormal.After icterus disappeared,the score of NBNA recovered normal.Conclusion NBNA and BAEP were sensitive and effective methods to diagnose early neonatal bilirubin cerebrosis contributing to the judge ment and treatment of the disease.
出处
《小儿急救医学》
2003年第4期217-219,共3页
Pediatric Emergency Medicine
