摘要
目的 分析重组人生长激素 (rhGH)对严重烧伤患者胰岛素样生长因子Ⅰ (IGF Ⅰ )、胰岛素样生长因子结合蛋白 3(IGFBP 3)及血糖的影响 ,寻找最佳用药时机。 方法 4 0例严重烧伤患者随机分为对照组、伤后第 7～ 9天开始治疗组 (治疗组 1)和伤后第 10～ 14天开始治疗组 (治疗组2 )。观察伤后第 1、3、5、7、10、14、2 1天IGF Ⅰ、IGFBP 3、血糖动态变化并进行分析比较。结果 治疗组 1和治疗组 2应用rhGH后 ,上述 3项指标均有升高 ,其中IGFBP 3和血糖与对照组比较 ,差异有显著性意义 (P <0 .0 5 )。治疗组 1与治疗组 2比较 ,用药后各时相点的 3项指标差异无显著性意义 (P >0 .0 5 )。 结论 伤后第 7～ 9天是严重烧伤患者应用rhGH的较好时机。
Objective To investigate the effects of recombinant human growth hormone (rhGH) on the changes in serum insulin-like growth factor Ⅰ (IGF Ⅰ), IGF binding protein 3 (IGFBP 3) and blood sugar in severely burned patients,so as to validate the optimal time of rhGH administration. Methods Forty severely burned patients were enrolled in the study and were randomly divided into control (C ), treatment 1 (rhGH given from 7-9 PBD, T1) and treatment 2 (rhGH from 10～14 PBD, T2) groups. The dynamic changes in serum IGF Ⅰ, IGFBP 3 and blood sugar on the 1, 3, 5, 7, 10, 14 and 21 PBDs in all 3 groups of burn patients were determined, analyzed and compared with one another. Results The serum IGF Ⅰ, IGFBP 3 and blood sugar levels in T1 and T2 groups were higher than those in C group after the use of rhGH, especially the IGFBP 3 and blood sugar(P < 0.05). There was no difference of all the indices between T1 and T2 groups. Conclusion It might be optimal to give rhGH to severely burned patients during 7～9 PBDs [
出处
《中华烧伤杂志》
CAS
CSCD
2003年第4期213-215,共3页
Chinese Journal of Burns
