摘要
目的:探讨肾络瘀阻与肾纤维化之间的关系,为应用中药抗肾纤维化奠定理论基础。方法:以放射免疫测定法测定肾病观察A组与肾病观察B组各47例患者血清中层粘蛋白(LN)、Ⅳ型胶元(ColⅣ),用双机体夹心ELISA法测定转化生长因子-β_1(TGF-β_1),并以30名健康人为对照,对肾络瘀阻程度与血清肾纤维化指标之间作相关性分析。结果:(1)肾病观察A组患者的TGF-β_1、LN、ColⅣ均显著高于肾病观察B组患者;后者又显著高于健康对照组;(2)肾络瘀阻程度与肾纤维化程度密切相关;(3)血府逐瘀汤不仅可以改善肾络瘀阻的程度,而且可以降低肾纤维化指标。结论:肾络瘀阻是肾纤维化的中医主要本质之一,在一定程度上,肾络瘀阻的程度可以反映肾纤维化的程度;血府逐瘀汤能降低血清肾纤维化的指标。
Objective:Exploring the relationship between Kidney Collateral Stasis (KCS) and Renal Fibrosis (RF) to lay a theoretical foundation of using traditional Chinese medicine (TCM) against RF. Methods: Laminin(LN),Collagen TV (ColIV )were assessed by radioimmunoassay method in 47 patients with nephropathy as Group A, 47 patients as Group B and 30 normal people as control group. Transforming Growth Factor -β1 (TGF -β1) was also examined by ELISA method in all groups. The correlation between the degrees of KCS and the parameters such as LN, Col IV , ,TGF -β1 was examined. Results : (1)TGF - β1 , LN, ColIV in the sera of the patients in group A were markedly higher than those in the patients in group B, but the latter were much higher than those in healthy subjects ; (2)Degrees of KCS correlated closely with those of RF; (3)Xuefu Zhuyu Decoction (XFZYD) could improve KCS and suppress the serum RF indexes.Conclusion:KCS is one of the main features in RF as TCM. The degrees of KCS might reflect those of RF to a certain extent. XFZYD might be efficient to RF.
出处
《中国中西医结合肾病杂志》
2003年第8期458-459,共2页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
浙江省教育厅基金(No.2002XTQ03)
关键词
肾络瘀阻
肾纤维化
转化生长因子-Β1
层粘蛋白
Ⅳ型胶元
活血化瘀
Kidney Collateral Stasis(KCS) Renal fibrosis(RF) Transforming Growth Factor-β1 (TGF- β1) Laminin (LN) Collagen IV(ColIV)
