摘要
本文应用免疫组织化学方法检测140例急、慢性肝炎患者肝组织内CMV抗原,发现15例阳性(10.7%),有9例同时存在HBV感染,其中3例为三重感染。15例CMV抗原阳性肝炎中,11例为慢性肝炎。以同法检测20例肝细胞性肝癌患者肝组织中CMV抗原,发现1例阳性。结果提示CMV感染为病毒性肝炎的病因之一;CMV肝炎与其他病毒性肝炎及慢性肝脏疾病可同时存在;CMV肝炎可能存在慢性化倾向。
Intrahepatic CMV antigen was detected in 140 cases with acute and chronic
hepatitis and in 20 cases with hepatocellular carcinoma (HCC) by indirect enzyme-
labeled technique. Intrahepatic CMV antigen was detected in 15 out of 140 cases
with viral hepatitis, and 1 out of 20 cases with HCC; Hepatitis B virus infection
was imposed on 9 of the 15 cases with positive CMV antigen, interestingly, 3 out
of the 9 cases with HBV superinfection were proved to be victims of multiple-
Infection. In histopathology, 11 out of 15 cases with positive CMV antigen were
characteristic of chronic hepatitis. In addition, CMV antigen positive hepatocytes
were all limited to pseudo--nodules instead of carcinomous tissues in 1 case with
HCC. All finding suggested that CMV infection could be one of the responsible
agents for viral hepatitis in China; CMV associated hepatitis could he coexisted
with HBV as well as other chronic liver diseases, leading to chronicity of the di-
sease.
出处
《临床肝胆病杂志》
CAS
1992年第3期121-124,共4页
Journal of Clinical Hepatology
关键词
巨细胞病毒
乙肝病毒
免疫病理
Cytomegalovirus (CMV)
Hepatitis B virus
Viral hepatitis
Immunopathology
