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瘦素与肝纤维化 被引量：2

Leptin and hepatic fibrosis
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摘要 1994年Zhang等人通过定向克隆技术首次发现了ob基因和该基因编码的蛋白产物-瘦素,瘦素的发现给肥胖及能量代谢领域带来了一次重大突破[1].瘦素不仅仅只对能量代谢起作用,它在病理生理学上的影响涉及许多系统.
作者 贾丽萍 戴立里
机构地区 重庆医科大学附属第二医院消化科
出处 《胃肠病学和肝病学杂志》 CAS 2003年第4期398-400,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 瘦素 肝纤维化 瘦素受佛 信号传递 生物学作用 Leptin, Hepatic fibrosis, Hepatic stellate cell
分类号 R575.2 [医药卫生—消化系统] Q51 [生物学—生物化学]
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参考文献21

  • 1Saxena NK, lkeda K, Rockey DC, et al. leptin in hepatic fibrosis : evidence for increased collagen production in stellate cells and lean littermates. Hepatology, 2002,35(4) :762-771.
  • 2Galli A, Crabb D, Price D, et al. Peroxisome proliferator-activated receptor γ transcriptional activation is involved in platelet-defived growth factor-induced proliferation of human hepatic stellate cells. Hepatology, 2000,31 :101-108.
  • 3Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994;372(6505):425-432.
  • 4Ahima RS, Elier JS. Leptin. Annu Rev Phsiol, 2000,62 : 413-437.
  • 5Votani S, Bjorback C, Tomoe J, et al. Functional properties of leptin receptor isoforms : internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes, 1999,48(2) :279-286.
  • 6Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell,2001,104(4) :531-543.
  • 7Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concerntrations in normal weight and obese humans. N Engl J Med, 1996,334 ( 5 ) : 292-295.
  • 8Lollmann B, Gruninger S. Stricker-Krongard A, et al. Detection and quantification of the leptin receptor splice variants OB-Ra, b and e in different mouse tissues. Biochem Biophys Ras Commun, 1997,238.(2):648-652.
  • 9Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 2001,15 (14) :2565-2571.
  • 10Zhao AZ, Shinohara MM, Huang D, et al. Leptin induces insulin-like signaling that antagonizes c AMP elevation by glucagons in hepatocytes. J Biol Chem,2000,275(15) : 11348-11354.

同被引文献25

  • 1沈磊,周晶,雷伟,魏芸,沈志祥,罗和生.瘦素及其受体与原发性肝癌关系的初步研究[J].中华肝脏病杂志,2006,14(10):777-779. 被引量：11
  • 2徐连根,周晶,雷伟,沈志祥.瘦素及其受体在肝癌组织中的表达及意义[J].胃肠病学和肝病学杂志,2006,15(5):502-504. 被引量：6
  • 3Zhang YR, Proenca M, Maffei M, et al. Positional cloning of the mouse ob gene and its human homologue[J]. Nature, 1994, 372: 425-432.
  • 4Tartaglia LM, Dembski X, Weng N, et al. Identification and expression cloning of a teptin receptor, OB-R [J]. Cell, 1995, 83:1 263-1 271.
  • 5Mareel M, Leroy A. Clinical, cellular, and molecular aspects of cancer invasion[J]. Physiol Rev, 2003, 83 337 -376.
  • 6Somasundar P,Yu AK,Vona-Davis L,et al.Differential effects 0fleptin on cancerin vitro.Surgi Res,2003,113(1):50-55.
  • 7Hardwick JC,Van Den Brink GR,Offerhans G J,et al.Leptin is a growth factor for colonic epithelial cells.Gastroenterology,2001,121 (1):79-90.
  • 8Hu X,Juneja SC,Maihle NJ,et al.Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development.J Natl Cancer Inst,2002,94(22):1704-1711.
  • 9Stattin P,Soderberg S,Hallmans G,et al.Leptin is associated with increased prostate cancer risk:a nested case-referent study.J Clin Endocrinol Metab,2001,86(3):1341-1345.
  • 10Hino M,Nakao T,Yamane T,et al.Leptin receptor and leukemia.Leuk Lymphoma,2000,36(5-6):457-461.

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胃肠病学和肝病学杂志
2003年 第4期

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