摘要
目的 :探讨中枢神经系统感染性疾病的病原学特点。方法 :分别用双抗体夹心ELISA法和传统的细菌及真菌培养等方法检测患者血清IgM ,IgG抗体和脑脊髓液中病原体。结果 :82 3例中枢神经系统急症患者中有 12 6例 (15 .3%)单纯疱疹病毒IgM和 /或IgG阳性 ,其中 10岁以下年龄为高峰。 10 (1.2 %)例巨细胞病毒特异性IgM和 /或IgG阳性 ;8(0 .97%)例水痘 带状疱疹病毒特异性IgM和 /或IgG阳性 ;7(0 .85 %)例为结核性脑膜炎 ;6 (0 .72 %)例为新生隐球菌性脑膜炎 ;1(0 .12 %)例为脑膜炎球菌性脑膜炎。结论 :病毒 ,特别是单纯疱疹病毒 ,是中枢神经系统感染性疾病的常见病原 ;结核杆菌和新生隐球菌感染也占一定比例。
Objective To determine the etiological characteristics of infectious diseases in the central neural system(CNS) . Methods The serum and cerebral spinal fluid of acute patients in the CNS were detected for virus-specific IgM ,IgG and pathogens with enzyme-linked immunosorbent assay as well as traditional bacterial and fungal culture.Results Of the 823 patients,126 (15.3%) patients were positive herpes simplex virus(HSV)-specific IgM and/or IgG, of which the maximum morbidity was under 10 years;10(1.2%) were positive cytomegalovirus specific IgM and/or IgG;8(0.97%)were positive varicella-zoster virus specific IgM and/or IgG; 7(0.85%) were diagnosed as tubercular meningitis; 6(0.72%) as cryptocococcs meningitis and 1(0.12%) as meningococcic meningitis.Conclusion Viruses,especially herpes simplex viruses are the common causative agents of infectious diseases of the CNS, in which mycobacterium tuberculosis and cryptocococcus neoformans are conspicuous.
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第4期412-414,共3页
Bulletin of Hunan Medical University
基金
湖南省重点学科建设项目经费资助
关键词
中枢神经系统感染性疾病
病原学
研究
脑炎
脑膜炎
单纯疱疹
结核杆菌
新生隐球茵
encephalitis
meningitis
herpes simplex
mycobacterium tuberculosis
cryptocococcus neoformans
central neural system
enzyme-linked immunosorbent assay
