摘要
目的 :探讨血浆NO及D 二聚体含量与原发性高血压患者血压水平、危险分层及靶器官损害的关系及依那普利和特拉唑嗪对其的影响。方法 :5 5例 1,2级原发性高血压患者随机分为两组 ,分别接受依那普利和特拉唑嗪治疗 8周 ;治疗前后检测血浆NO和D 二聚体含量。结果 :高血压患者血浆NO低于正常对照组 (P<0 .0 0 1) ;D 二聚体含量高于正常对照组 (P <0 .0 1) ;血浆NO和D 二聚体含量与血压级别、危险分层、靶器官受损有关。依那普利和特拉唑嗪均能有效降压 ,同时可使血浆NO增高 (P <0 .0 0 1) ,D 二聚体含量下降 (P <0 .0 1)。结论 :高血压患者早期血浆NO降低、D 二聚体含量增高 ,即存在内皮细胞的损伤及微血栓形成。依那普利和特拉唑嗪可通过促进NO合成改善内皮细胞功能及血栓前状态。
Objective To investigate the relationship among serum nitric oxide,D-dimer,blood pressure,dangerous states and target organ damage in essential hypertension and to evaluate the effects of enalapril and terazosin. Methods Fifty-five patients were randomized into the enalapril group and terazosin group,each group receiving enalapril and terazosin respectively for 8 weeks . Serum nitric oxide and D-dimer were measured before and after the treatment. Results Serum nitric oxide was lower (P<0.001)but D-dimer was higher(P<0.01) in the hypertensions than those in the controls. Serum nitric oxide and D-dimer were related to different levels of blood pressure ,dangerous states and target organ damage;Both enalapril and terazosin could reduce the level of blood pressure; Both could increase the serum nitric oxide (P<0.001)and decrease the D-dimer(P<0.01). Conclusion Endothelial dysfunction and microthrombin can be found in the early stage of essential hypertension. Both enalapril and terazosin could improve the endothelial function and prothrombotic state by promoting the synthesis of nitric oxide.
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第4期382-384,共3页
Bulletin of Hunan Medical University
