摘要
目的 研究枸杞多糖 (LBP)对雄性大鼠睾丸组织损伤的保护作用 ,找出LBP最佳作用剂量。方法 通过给雄性Wistar大鼠灌胃不同剂量的LBP〔0 ,10 ,5 0 ,10 0及 2 0 0mg/ (kg·d)〕2周后温水浴造模观察大鼠血清性激素水平、睾丸、附睾的脏器系数、睾丸组织中超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量及睾丸组织形态学改变。结果 LBP可使睾丸损伤大鼠血清性激素水平升高 ;增加睾丸、附睾的脏器系数 ;提高大鼠睾丸组织SOD活性 ,降低MDA含量 ;使受损的睾丸组织恢复到接近正常。结论 LBP对大鼠睾丸损伤具有保护作用 ,10mg/ (kg·d)为其最佳剂量。
Objective To study the protective effect of lycium barbarum polysaccharides(LBP) on male rats' testis organ damage and find out the optimal dose of LBP.Methods Different doses of LBP 〔0,10,50,100 and 200?mg/(kg·d)〕 were poured into the male Wistar rats' stomach.Trauma model of testicle were constructed by warm bath after two weeks.Serum sexual hormone levels,organ index of testis and epididymides,superoxide dismutase (SOD) activity,malonic aldehyde (MDA) contents and morphological change of the testis were observed.Results LBP could elevate the serum sexual hormone levels and organ index of testis and epididymides,increase the activity of SOD and decrease the contents of MDA in testis tissue;and make the damaged testis recover to near normal.Conclusion LBP has the protective effect on damaged rat testis and the optimal dose is 10?mg/(kg.d).
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第9期1052-1054,共3页
Chinese Journal of Public Health
基金
湖北省科技厅重点攻关课题 (2 0 0 1AA30 7B)
关键词
枸杞多糖
性激素
抗氧化
保护作用
lycium barbarum polysaccharide
sex hormone
anti-oxidative
protective effect
