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抗人膀胱癌/抗VEGF双功能基因抗体对血管内皮细胞增殖的影响

Effect of bispecific antibody(Bs Ab,anti-human bladder cancer/anti-VEGF) on the proliferation of vascular endothelial cells in vitro
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摘要 目的 研究抗人膀胱癌 /抗 VEGF双功能基因抗体体外抗血管内皮细胞增殖的活性。方法  MTT法检测抗人膀胱癌 /抗 VEGF双功能基因抗体对血管内皮细胞增殖的活性。结果 抗人膀胱癌 /抗 VEGF双功能基因抗体可以明显抑制血管内皮细胞增殖。结论 抗人膀胱癌 /抗VEGF双功能基因抗体能通过抗肿瘤新生血管形成而发挥抗肿瘤作用 ,从而为膀胱癌的治疗提供了一种新的思路。 Objective To study the inhibition rate of BsAb against the proliferation of vascular endothelial cells in vitro.Methods MTT technique was adopted.Results BsAb could significantly inhibit the proliferation of vascular endothelial cells.Conclusions BsAb could inhibit angiogenesis.It may become a new method for human bladder cancer treatment.
出处 《中国老年学杂志》 CAS CSCD 北大核心 2003年第9期578-579,共2页 Chinese Journal of Gerontology
基金 国家自然科学基金资助项目 (30 1 70 940 )
关键词 抗人膀胱癌/抗VEGF双功能基因抗体 血管内皮细胞 细胞增殖 VEGF 血管生成 MTT法 Bispecific gene antibody Vascular endothelial cells Proliferation
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