摘要
Cyclandelate was separated using a new derivative of mono 3 O phenylcarbamoyl β CD as chiral selector.It was discussed the effect of the concentration of chiral selector,pH,the concentration of buffer and organic modifier on the resolution.The results show that the chiral resolution(Rs)is strongly influenced by the concentrations of mono 3 O phenylcarbamoyl β CD and the pH of the background electrolyte.Under the same experimental conditions,cyclandelate cannot be separated by β CD and the commonly used HP β CD and DM β CD.This showed that the chiral separating ability of mono 3 O phenylcarbamoyl β CD is stronger.The recogition mechanism of mono 3 O phenylcarbamoyl β CD on these chiral drugs in the cyclodextrin modified capillary zone electrophoresis were discussed.
Cyclandelate was separated using a new derivative of mono 3 O phenylcarbamoyl β CD as chiral selector.It was discussed the effect of the concentration of chiral selector,pH,the concentration of buffer and organic modifier on the resolution.The results show that the chiral resolution(Rs)is strongly influenced by the concentrations of mono 3 O phenylcarbamoyl β CD and the pH of the background electrolyte.Under the same experimental conditions,cyclandelate cannot be separated by β CD and the commonly used HP β CD and DM β CD.This showed that the chiral separating ability of mono 3 O phenylcarbamoyl β CD is stronger.The recogition mechanism of mono 3 O phenylcarbamoyl β CD on these chiral drugs in the cyclodextrin modified capillary zone electrophoresis were discussed.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2003年第5期668-669,F003,共3页
Chemical Research and Application
关键词
毛细管区带电泳法
拆分
手性药物
环扁桃酯
手性添加剂
Capillary zone electrophoresis
Chiral drugs
Enantiomeric separation
Chiral additive
