摘要
随着生物技术的不断发展 ,近年来对鞘脂类物质的研究不断深入。鞘脂质除了在细胞骨架的迁移、血管发生、胚胎发育和信号转导等方面起重要作用外 ,最近的研究发现鞘脂及其代谢物 (神经酰胺、鞘氨醇、鞘氨醇 1 磷酸 )能诱导多种肿瘤和恶性增殖细胞 (如腺癌、结肠癌、肝肿瘤、肺癌、鼻咽癌等 )的凋亡。
Over the last decade, considerable progress has been made in the study of sphingolipids with the development of biological techniques. Sphingolipids play important roles in diverse physiological process, including cytoskeleton migration, angiogenesis, embryonic development and signal transduction. Except for this, the lastest evidence has suggested that sphingolipids and their metabolite (ceramide, sphingosine, sphingosine 1-phosphate) can induce apoptosis in a wide variety of tumor cell lines such as LoVo HT29, Bel7402, A549, CNE2 cells. This paper is attempted to review the recent advances of investigation into the relationship between sphingolipids and apoptosis.
出处
《生理科学进展》
CAS
CSCD
北大核心
2003年第3期217-221,共5页
Progress in Physiological Sciences
基金
十五重大项目"86 3"(2 0 0 1AA2 12 2 91)资助课题
关键词
鞘脂
细胞凋亡
神经酰胺
鞘氨醇
Ceramide
Sphingosine
Sphingosine 1-phosphate
Apoptosis
