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链球菌组蛋白样蛋白对人脐静脉血管内皮细胞产生TNF-α的影响 被引量：1

Effects of Streptococcus Histone-Like Protein on the Production of TNF-α by Hu- man Umbilical Cord Vein Vascular Endothelial Cells
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摘要 研究链球菌HlpA对HUVEC产生TNF-α的作用。用1929成纤维细胞的细胞毒实验检测TNF-α活性。链球菌HlpA(0-80μg/ml)在体外以剂量和时间依赖方式促进HUVEC过量产生TNF-α(P<0.05)。LTA和HlpA的混合物对TNF-α的产生呈协同增强作用(P<0.05);抗HlpA和肝素则起抑制作用。 To evaluate the effect of Streptococcus HlpA on the production of TNF-α by human umbilical cord vein vascular endothelial cells (HUVEC ) , the activity of TNF-α was determined by means of cytotoxicity assay with L929 cells. Streptococcus HlpA (0-80 μg/ml ) could induce an over-production of TNF-α by HUVEC cells in a dose and time dependent manner in vitro. There was a synergistic enhancing effect of the production of TNF-αinduced by a mixture of LTA and HlpA, and the anti-HlpA and heparin showed an inhibitory effect.
作者 张力平 平国玲 李卫红 沈海中 张海燕 张红春 靖学芳 李玉兰
机构地区 首都医科大学微生物学教研室 细胞生物学教研室
出处 《上海免疫学杂志》 CSCD 北大核心 2003年第5期311-313,共3页 Shanghai Journal of Immunology
基金 北京市自然科学基金资助项目(No.7992003)
关键词 链球菌 人脐带静脉血管内皮细胞 肿瘤坏死因子-Α Streptococcus HUVEC TNF-α
分类号 R378.12 [医药卫生—病原生物学]
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参考文献10

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二级参考文献9

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共引文献2

同被引文献9

  • 1吴强,庞学雯,钱晓萍,吴江声,陈慰峰.胸腺细胞对胸腺止皮细胞分泌IL-6的促进作用[J].中华微生物学和免疫学杂志,1996,16(6):418-421. 被引量：6
  • 2Okamoto M, Oshikawa T, Tano T, et al. Involvement of toll-like receptor 4 signaling in interferon-γproduction and antitumor effect by streptococcal agent OK-432[J]. Natl Cancer Inst, 2003, 95 (4) : 316 - 326.
  • 3Mirlashari MR, Lyberg T. Expression and involvement of Toll-like receptors(TLR)2, TLR4 and CDI4 in monocyte TNF-α production induction by lipopolysaccharides from Neisseria meningitides [J]. Med Sci Monit, 2003, 9(8): 316-324.
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  • 6Oshikawa T, Okamoto M, Tano T, et al. Antitumor effect of OK- 432-derived DNA one of the active constituents of OK-432, a streptococcal immunotherapeutie agent [J]. Immunother, 2006, 29 (2) : 143 - 149.
  • 7Okamoto M, Oshikawa T, Tano T, et al. Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and toll-like receptor 4 singnaling[J]. Immunother, 2006, 29(1): 78-86.
  • 8李彦芹,郑群,王艳,李卫红,朱俊平,平国玲,范东瀛,张力平.链球菌蛋白对人肝癌Bel-7402细胞的增殖抑制作用及其分子机制[J].中国组织工程研究与临床康复,2007,11(43):8733-8736. 被引量：3
  • 9王艳,平国玲,李卫红,朱俊萍,曹宁,张力平.链球菌蛋白对5-氟尿嘧啶引起的小鼠脾细胞增殖抑制及凋亡的拮抗作用[J].免疫学杂志,2008,24(2):130-134. 被引量：5

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上海免疫学杂志
2003年 第5期

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